* Denotes co-first authorship, § denotes co-second authorship, and † denotes co-corresponding authorship.

455. Yang JL, Yamada-Hunter SA§, Labanieh L§, Sotillo E, Cheah JS, Roberts DS, Mackall CL, Bertozzi CR, Ting AY. Directed evolution of genetically encoded LYTACs for cell-mediated delivery. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2320053121.

454. Guzmán LE, Cambier CJ, Cheng TY, Naqvi KF, Shiloh MU, Moody DB, Bertozzi CR. Bioorthogonal Metabolic Labeling of the Virulence Factor Phenolic Glycolipid in Mycobacteria. ACS Chem Biol. 2024 Mar 15;19(3):707-717.

453. Bertozzi CR, Schanze KS. Celebrating the 10th Anniversary of ACS Central Science. ACS Cent Sci. 2024 Jan 24;10(1):1-3.

452. Stewart N, Daly J, Drummond-Guy O, Krishnamoorthy V, Stark JC, Riley NM, Williams KC, Bertozzi CR, Wisnovsky S. The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation. J Biol Chem. 2023 Dec 21;300(2):105579.

451. Delaveris CS, Wang CL, Riley NM, Li S, Kulkarni RU†, Bertozzi CR†. Microglia Mediate Contact-Independent Neuronal Network Remodeling via Secreted Neuraminidase-3 Associated with Extracellular Vesicles. ACS Cent Sci. 2023 Oct 31;9(11):2108-2114.

450. Tender GS, Bertozzi CR. Bringing enzymes to the proximity party. RSC Chem Biol. 2023 Sep 29;4(12):986-1002.

449. Ahn G, Riley NM, Kamber RA, Wisnovsky S, Moncayo von Hase S, Bassik MC, Banik SM, Bertozzi CR. Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras. Science. 2023 Oct 20;382(6668):eadf6249.

448. Peltan EL, Riley NM, Flynn RA, Roberts DS, Bertozzi CR. Galectin-3 does not interact with RNA directly. Glycobiology. 2023 Oct 10:cwad076.

447. Chongsaritsinsuk J*, Steigmeyer AD*, Mahoney KE*, Rosenfeld MA*, Lucas TM, Smith CM, Li A, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Judy Shon D, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Lemmon MA, Amaro RE, Malaker SA. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. Nat Commun. 2023 Oct 4;14(1):6169.

446. Ealand CS*, Sewcharran A*, Peters JS, Gordhan BG, Kamariza M, Bertozzi CR, Waja Z, Martinson NA, Kana BD. The performance of tongue swabs for detection of pulmonary tuberculosis. Front Cell Infect Microbiol. 2023 Sep 6;13:1186191.

445. Pedram K*, Shon DJ*, Tender GS*, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Nat Biotechnol. 2023 Aug 3.

444. Szijj PA, Gray MA§, Ribi MK§, Bahou C, Nogueira JCF, Bertozzi CR, Chudasama V. Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer. Nat Chem. 2023 Jul 24.

443. Miller CL*, Sagiv-Barfi I*, Neuhöfer P, Czerwinski DK, Bertozzi CR†, Cochran JR†, Levy R†. Targeted TLR9 Agonist Elicits Effective Antitumor Immunity against Spontaneously Arising Breast Tumors. J Immunol. 2023 Jul 15;211(2):295-305.

442. Wei W*, Riley NM*, Lyu X*, Shen X, Guo J, Raun SH, Zhao M, Moya-Garzon MD, Basu H, Sheng-Hwa Tung A, Li VL, Huang W, Wiggenhorn AL, Svensson KJ, Snyder MP, Bertozzi CR, Long JZ. Organism-wide, cell-type-specific secretome mapping of exercise training in mice. Cell Metab. 2023 Apr 28:S1550-4131(23)00138-9.

441. Hollander MJ, Malaker SA, Riley NM, Perez I, Abney NM, Gray MA, Maxson JE, Cochran JR, Bertozzi CR. Mutational screens highlight glycosylation as a modulator of colony-stimulating factor 3 receptor (CSF3R) activity. J Biol Chem. 2023 Apr 26:104755.

440. Dai T, Xie J, Buonomo JA, Moreno A, Banaei N, Bertozzi CR, Rao J. Bioluminogenic Probe for Rapid, Ultrasensitive Detection of β-Lactam-Resistant Bacteria. Anal Chem. 2023 May 9;95(18):7329-7335.

439. Smith BAH*, Deutzmann A*, Correa KM, Delaveris CS, Dhanasekaran R, Dove CG, Sullivan DK, Wisnovsky S, Stark JC, Pluvinage JV, Swaminathan S, Riley NM, Rajan A, Majeti R, Felsher DW†, Bertozzi CR†. MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2215376120.

438. Hollenhorst MA, Tiemeyer KH, Mahoney KE, Aoki K, Ishihara M, Lowery SC, Rangel-Angarita V, Bertozzi CR†, Malaker SA†. Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation. J Thromb Haemost. 2023 Apr;21(4):995-1009.

437. Scott E, Hodgson K, Calle B, Turner H, Cheung K, Bermudez A, Marques FJG, Pye H, Yo EC, Islam K, Oo HZ, McClurg UL, Wilson L, Thomas H, Frame FM, Orozco-Moreno M, Bastian K, Arredondo HM, Roustan C, Gray MA, Kelly L, Tolson A, Mellor E, Hysenaj G, Goode EA, Garnham R, Duxfield A, Heavey S, Stopka-Farooqui U, Haider A, Freeman A, Singh S, Johnston EW, Punwani S, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Bogdan D, Westaby D, Fowler G, Flohr P, Yuan W, Sharp A, de Bono J, Maitland NJ, Wisnovsky S, Bertozzi CR, Heer R, Guerrero RH, Daugaard M, Leivo J, Whitaker H, Pitteri S, Wang N, Elliott DJ, Schumann B, Munkley J. Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Oncogene. 2023 Mar;42(12):926-937.

436. Riley NM, Wen RM, Bertozzi CR, Brooks JD, Pitteri SJ. Measuring the multifaceted roles of mucin-domain glycoproteins in cancer. Adv Cancer Res. 2023;157:83-121.

435. Peters JS, McIvor A, Papadopoulos AO, Masangana T, Gordhan BG, Waja Z, Otwombe K, Letutu M, Kamariza M, Sterling TR, Bertozzi CR, Martinson NA, Kana BD. Differentially culturable tubercle bacteria as a measure of tuberculosis treatment response. Front Cell Infect Microbiol. 2023 Jan 12;12:1064148.

434. Pensinger DA, Fisher AT, Dobrila HA, Van Treuren W, Gardner JO, Higginbottom SK, Carter MM, Schumann B, Bertozzi CR, Anikst V, Martin C, Robilotti EV, Chow JM, Buck RH, Tompkins LS, Sonnenburg JL, Hryckowian AJ. Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates. Infect Immun. 2023 Feb 16;91(2):e0057022.

433. Wu CT, Lidsky PV*, Xiao Y*, Cheng R*, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R†, Jackson PK†. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Cell. 2023 Jan 5;186(1):112-130.e20.

432. Riley NM, Bertozzi CR. Deciphering O-glycoprotease substrate preferences with O-Pair Search. Mol Omics. 2022 Dec 5;18(10):908-922.

431. Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, Pearce OMT, Pearce EL, Bertozzi CR, Zippelius A, Läubli H. Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade. Sci Transl Med. 2022 Nov 2;14(669):eabj1270.

430. Cioce A, Calle B, Rizou T, Lowery SC, Bridgeman VL, Mahoney KE, Marchesi A, Bineva-Todd G, Flynn H, Li Z, Tastan OY, Roustan C, Soro-Barrio P, Rafiee MR, Garza-Garcia A, Antonopoulos A, Wood TM, Keenan T, Both P, Huang K, Parmeggian F, Snijders AP, Skehel M, Kjær S, Fascione MA, Bertozzi CR, Haslam SM, Flitsch SL, Malaker SA, Malanchi I, Schumann B. Cell-specific bioorthogonal tagging of glycoproteins. Nat Commun. 2022 Oct 25;13(1):6237.

429. Richards CM*, Jabs S*, Qiao W*, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T†, Carette JE†. The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 Oct 7;378(6615):eabn5648.

428. Pedram K, Laqtom NN, Shon DJ, Di Spiezio A, Riley NM, Saftig P, Abu-Remaileh M, Bertozzi CR. Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2117105119.

427. Biering SB*, Sarnik SA*, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E†, Konermann S†, Hsu PD†. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Nat Genet. 2022 Aug;54(8):1078-1089.

426. Mabe NW*, Huang M*, Dalton GN, Alexe G, Schaefer DA, Geraghty AC, Robichaud AL, Conway AS, Khalid D, Mader MM, Belk JA, Ross KN, Sheffer M, Linde MH, Ly N, Yao W, Rotiroti MC, Smith BAH, Wernig M, Bertozzi CR, Monje M, Mitsiades CS, Majeti R, Satpathy AT, Stegmaier K, Majzner RG. Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1. Nat Cancer. 2022 Jul 11.

425. Malaker SA*, Riley NM*, Shon DJ, Pedram K, Krishnan V, Dorigo O, Bertozzi CR. Revealing the human mucinome. Nat Commun. 2022 Jun 20;13(1):3542.

424. Daly J, Sarkar S, Natoni A, Stark JC, Riley NM, Bertozzi CR, Carlsten M†, O'Dwyer ME†. Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses. Blood Adv. 2022 Jun 14;6(11):3352-3366.

423. Lu CH, Pedram K, Tsai CT, Jones T 4th, Li X, Nakamoto ML, Bertozzi CR, Cui B. Membrane curvature regulates the spatial distribution of bulky glycoproteins. Nat Commun. 2022 Jun 2;13(1):3093.

422. Wisnovsky S†, Bertozzi CR†. Reading the glyco-code: New approaches to studying protein-carbohydrate interactions. Curr Opin Struct Biol. 2022 May 30;75:102395.

421. Weidenbacher PA, Rodriguez-Rivera FP, Sanyal M, Visser JA, Do J, Bertozzi CR, Kim PS. Chemically Modified Bacterial Sacculi as a Vaccine Microparticle Scaffold. ACS Chem Biol. 2022 May 20;17(5):1184-1196.

420. Kulkarni RU, Wang CL, Bertozzi CR. Analyzing nested experimental designs-A user-friendly resampling method to determine experimental significance. PLoS Comput Biol. 2022 May 2;18(5):e1010061.

419. Weidenbacher PA, Rodriguez-Rivera FP, Sanyal M, Visser JA, Do J, Bertozzi CR, Kim PS. Chemically Modified Bacterial Sacculi as a Vaccine Microparticle Scaffold. ACS Chem Biol. 2022 Apr 12.

418. Shon DJ, Fernandez D, Riley NM, Ferracane MJ, Bertozzi CR. Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences. J Biol Chem. 2022 Apr 8:101917.

417. Barr DA, Schutz C, Balfour A, Shey M, Kamariza M, Bertozzi CR, de Wet TJ, Dinkele R, Ward A, Haigh KA, Kanyik JP, Mizrahi V, Nicol MP, Wilkinson RJ, Lalloo DG, Warner DF, Meintjes G, Davies G. Serial measurement of M. tuberculosis in blood from critically-ill patients with HIV-associated tuberculosis. EBioMedicine. 2022 Mar 21;78:103949.

416. Yao Y, Kim G, Shafer S, Chen Z, Kubo S, Ji Y, Luo J, Yang W, Perner SP, Kanellopoulou C, Park AY, Jiang P, Li J, Baris S, Aydiner EK, Ertem D, Mulder DJ, Warner N, Griffiths AM, Topf-Olivestone C, Kori M, Werner L, Ouahed J, Field M, Liu C, Schwarz B, Bosio CM, Ganesan S, Song J, Urlaub H, Oellerich T, Malaker SA, Zheng L, Bertozzi CR, Zhang Y, Matthews H, Montgomery W, Shih HY, Jiang J, Jones M, Baras A, Shuldiner A, Gonzaga-Jauregui C, Snapper SB, Muise AM, Shouval DS, Ozen A, Pan KT, Wu C, Lenardo MJ. Mucus sialylation determines intestinal host-commensal homeostasis. Cell. 2022 Mar 10:S0092-8674(22)00193-3.

415. Daly J, Sarkar S, Natoni A, Stark JC, Riley NM, Bertozzi CR, Carlsten M, O'Dwyer ME. Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses. Blood Adv. 2022 Mar 16:bloodadvances.2021006805.

414. Forcina GC, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi CR, Dixon SJ. Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2118646119.

413. Theruvath J, Menard M, Smith BAH, Linde MH, Coles GL, Dalton GN, Wu W, Kiru L, Delaidelli A, Sotillo E, Silberstein JL, Geraghty AC, Banuelos A, Radosevich MT, Dhingra S, Heitzeneder S, Tousley A, Lattin J, Xu P, Huang J, Nasholm N, He A, Kuo TC, Sangalang ERB, Pons J, Barkal A, Brewer RE, Marjon KD, Vilches-Moure JG, Marshall PL, Fernandes R, Monje M, Cochran JR, Sorensen PH, Daldrup-Link HE, Weissman IL, Sage J, Majeti R, Bertozzi CR, Weiss WA, Mackall CL, Majzner RG. Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. Nat Med. 2022 Feb;28(2):333-344.

412. Wei W, Riley NM, Lyu X, Bertozzi CR, Long JZ. Protocol for cell type-specific labeling, enrichment, and proteomic profiling of plasma proteins in mice. STAR Protoc. 2021 Dec 11;2(4):101014.

411. Bouchard G, Garcia-Marques FJ, Karacosta LG, Zhang W, Bermudez A, Riley NM, Varma S, Mehl LC, Benson JA, Shrager JB, Bertozzi CR, Pitteri SJ, Giaccia AJ, Plevritis SK. Multi-omics analysis of spatially distinct stromal cells reveals tumor-induced O-glycosylation of the CDK4-pRB axis in fibroblasts at the invasive tumor edge. Cancer Res. 2021 Dec 1:canres.1705.2021.

410. Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T. The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Sci Transl Med. 2021 Dec;13(622):eabg2919.

409. Miller CL*, Sagiv-Barfi I*, Neuhöfer P, Czerwinski DK, Artandi SE, Bertozzi CR, Levy R, Cochran JR. Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression. Cell Chem Biol. 2021 Nov 9:S2451-9456(21)00476-1.

408. Kamariza M*, Keyser SGL*, Utz A, Knapp BD, Ealand C, Ahn G, Cambier CJ, Chen T, Kana B, Huang KC, Bertozzi CR. Toward Point-of-Care Detection of Mycobacterium tuberculosis: A Brighter Solvatochromic Probe Detects Mycobacteria within Minutes. JACS Au. 2021 Jul 26;1(9):1368-1379.

407. Grabenstein S, Barnard KN, Anim M, Armoo A, Weichert WS, Bertozzi CR, Parrish CR, Willand-Charnley R. Deacetylated sialic acids modulates immune mediated cytotoxicity via the sialic acid-Siglec pathway. Glycobiology. 2021 Nov 18;31(10):1279-1294.

406. Malaker SA, Quanico J, Raffo-Romero A, Kobeissy F, Aboulouard S, Tierny D, Bertozzi CR, Fournier I, Salzet M. On-tissue spatially resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape. Cell Chem Biol. 2021 May 26:S2451-9456(21)00224-5.

405. Delaveris CS, Wilk AJ, Riley NM, Stark JC, Yang SS, Rogers AJ, Ranganath T, Nadeau KC; Stanford COVID-19 Biobank, Blish CA, Bertozzi CR. Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19. ACS Cent Sci. 2021 Apr 28;7(4):650-657.

404. Flynn RA, Pedram K, Malaker SA, Batista PJ, Smith BAH, Johnson AG, George BM, Majzoub K, Villalta PW, Carette JE, Bertozzi CR. Small RNAs are modified with N-glycans and displayed on the surface of living cells. Cell. 2021 Jun 10;184(12):3109-3124.e22.

403. *Cioce A, *Bineva-Todd G, Agbay AJ, Choi J, Wood TM, Debets MF, Browne WM, Douglas HL, Roustan C, Tastan OY, Kjaer S, Bush JT, Bertozzi CR, Schumann B. Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem Biol. 2021 Apr 9. Epub ahead of print.

402. Ahn G, Banik SM, Bertozzi CR. Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway. Cell Chem Biol. 2021 Jul 15;28(7):1072-1080.

401. Ahn G, Banik SM, Miller CL, Riley NM, Cochran JR, Bertozzi CR. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. Nat Chem Biol. 2021 Mar 25. Epub ahead of print.

400. *†Flynn RA, *Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, †Wilen CB, †Satpathy AT. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. Cell. 2021 Apr 29;184(9):2394-2411.e16.

399. Riley NM, Bertozzi CR, Pitteri SJ. A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry-Based Glycoproteomics. Mol Cell Proteomics. 2020 Dec 20;20:100029.

398. *Dinkele R, *Gessner S, McKerry A, Leonard B, Seldon R, Koch AS, Morrow C, Gqada M, Kamariza M, Bertozzi CR, Smith B, McLoud C, Kamholz A, Bryden W, Call C, Kaplan G, Mizrahi V, Wood R, Warner DF. Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols. PLoS Pathog. 2021 Feb 1;17(2):e1009262.

397. Wisnovsky S, Möckl L, Malaker SA, Pedram K, Hess GT, Riley NM, Gray MA, Smith BAH, Bassik MC, Moerner WE, Bertozzi CR. Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2015024118.

396. Smith BAH, Bertozzi CR. The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans. Nat Rev Drug Discov. 2021 Mar;20(3):217-243.

395. Delaveris CS, Chiu SH, Riley NM, Bertozzi CR. Modulation of immune cell reactivity with cis-binding Siglec agonists. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2012408118.

394. Cambier CJ, Banik SM, Buonomo JA, Bertozzi CR. Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity. Elife. 2020 Nov 23;9:e60648.

393. *Wei W, *Riley NM, Yang AC, Kim JT, Terrell SM, Li VL, Garcia-Contreras M, Bertozzi CR, Long JZ. Cell type-selective secretome profiling in vivo. Nat Chem Biol. 2020 Nov 16. Epub ahead of print.

392. Cortez FJ, Gebhart D, Robinson PV, Seftel D, Pourmandi N, Owyoung J, Bertozzi CR, Wilson DM, Maahs DM, Buckingham BA, Mills JR, Roforth MM, Pittock SJ, McKeon A, Page K, Wolf WA, Sanda S, Speake C, Greenbaum CJ, Tsai CT. Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR. PLoS One. 2020 Nov 13;15(11):e0242049.

391. Riley NM, Malaker SA, Bertozzi CR. Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis. Anal Chem. 2020 Nov 17;92(22):14878-14884.

390. *Lu L, *Riley NM, Shortreed MR, Bertozzi CR, Smith LM. O-Pair Search with MetaMorpheus for O-glycopeptide characterization. Nat Methods. 2020 Nov;17(11):1133-1138.

389. Imbert PRC, Saric A, Pedram K, Bertozzi CR, †Grinstein S, †Freeman SA. An Acquired and Endogenous Glycocalyx Forms a Bidirectional "Don't Eat" and "Don't Eat Me" Barrier to Phagocytosis. Curr Biol. 2020 Oct 19:S0960-9822(20)31495-0.

388. *Debets MF, *Tastan OY, Wisnovsky SP, Malaker SA, Angelis N, Moeckl LKR, Choi J, Flynn H, Wagner LJS, Bineva-Todd G, Antonopoulos A, Cioce A, Browne WM, Li Z, Briggs DC, Douglas HL, Hess GT, Agbay AJ, Roustan C, Kjaer S, Haslam SM, Snijders AP, Bassik MC, Moerner WE, Li VSW, Bertozzi CR, Schumann B. Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25293-25301.

387. Riley NM, Bertozzi CR, Pitteri SJ. A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry-based Glycoproteomics. Mol Cell Proteomics. 2020 Sep 16:mcp.R120.002277. doi: 10.1074/mcp.R120.002277. Epub ahead of print. PMID: 32938752.

386. Patterson B, Dinkele R, Gessner S, Morrow C, Kamariza M, Bertozzi CR, Kamholz A, Bryden W, Call C, Warner DF, Wood R. Sensitivity optimisation of tuberculosis bioaerosol sampling. PLoS One. 2020 Sep 3;15(9):e0238193. doi: 10.1371/journal.pone.0238193.

385. Shon DJ, Malaker SA, Pedram K, Yang E, Krishnan V, Dorigo O, Bertozzi CR. An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21299-21307.

384. *Dai T, *Xie J, Zhu Q, Kamariza M, Jiang K, Bertozzi CR, Rao J. A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis. J Am Chem Soc. 2020 Sep 9;142(36):15259-15264.

383. Gray MA, Stanczak MA, Mantuano NR, Xiao H, Pijnenborg JFA, Malaker SA, Miller CL, Weidenbacher PA, Tanzo JT, Ahn G, Woods EC, Läubli H, Bertozzi CR. Targeted glycan degradation potentiates the anticancer immune response in vivo. Nat Chem Biol. 2020 Dec;16(12):1376-1384.

382. Banik SM, Pedram K, Wisnovsky S, Ahn G, Riley NM, Bertozzi CR. Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature. 2020 Aug;584(7820):291-297.

381. Xie MM, Bertozzi CR, Wang TT. Immunoglobulin E sialylation regulates allergic responses. Immunol Cell Biol. 2020 Sep;98(8):617-619.

380. Yang AC, Stevens MY, Chen MB, Lee DP, Stähli D, Gate D, Contrepois K, Chen W, Iram T, Zhang L, Vest RT, Chaney A, Lehallier B, Olsson N, du Bois H, Hsieh R, Cropper HC, Berdnik D, Li L, Wang EY, Traber GM, Bertozzi CR, Luo J, Snyder MP, Elias JE, Quake SR, James ML, Wyss-Coray T. Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature. 2020, 583(7816):425-430.

379. Riley NM, Malaker SA, Driessen MD, Bertozzi CR. Optimal Dissociation Methods Differ for N- and O-Glycopeptides. J Proteome Res. 2020, 19(8):3286-3301.

378. *Delaveris CS, *Webster ER, Banik SM, Boxer SG, Bertozzi CR. Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus. Proc Natl Acad Sci U S A. 2020, 117(23), 12643-12650.

377. Schumann B, Malaker SA, Wisnovsky SP, Debets MF, Agbay AJ, Fernandez D, Wagner LJS, Lin L, Li Z, Choi J, Fox DM, Peh J, Gray MA, Pedram K, Kohler JJ, Mrksich M, Bertozzi CR. Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells. Mol Cell. 2020, S1097-2765(20)30198-2.

376. Stenger-Smith J, Kamariza M, Chakraborty I, Ouattara R, Bertozzi CR, Mascharak PK. Enhanced Bactericidal Effects of Pyrazinamide Toward Mycobacterium smegmatis and Mycobacterium tuberculosis upon Conjugation to a {Au(I)-triphenylphosphine}+ Moiety. ACS Omega. 2020, 5(12), 6826-6833.

375. Wang ST, Gray MA, Xuan S, Lin Y, Byrnes J, Nguyen AI, Todorova N, Stevens MM, Bertozzi CR, Zuckermann RN, Gang O. DNA origami protection and molecular interfacing through engineered sequence-defined peptoids. Proc Natl Acad Sci U S A. 2020, 117(12),6339-6348.

374. *Shao, Z.; *Flynn, R. A.; *Crowe, J. L.; *Zhu, Y.; Liang, J.; Jiang, W.; Aryan, F.; Aoude, P.; Bertozzi, C. R.; Estes, V. M.; Lee, B. J.; Bhagat, G.; †Zha, S.; †Calo, E. DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. Nature, 2020, 579(7798),291-296.

373. Marschallinger, J.; Iram, T.; Zardeneta, M.; Lee, S. E.; Lehallier, B.; Haney, M. S.; Pluvinage, J. V.; Mathur, V.; Hahn, O.; Morgens, D. W.; Kim, J.; Tevini, J.; Felder, T. K.; Wolinski, H.; Bertozzi, C. R.; Bassik, M. C.; Aigner, L.; Wyss-Coray, T. Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain. Nat. Neurosci. 2020, 23(2),194-208.

372. Bule, P.; Chuzel, L.; Blagova, E.; Wu, L.; Gray, M. A.; Henrissat, B.; Rapp, E.; Bertozzi, C. R.; Taron, C. H.; Davies, G. J. Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action. Nat. Comm. 2019, 10(1),4816.

371. Tsui, C. K.; Barfield, R. M.; Fischer, C. R.; Morgens, D. W.; Li, A.; Smith, B. A. H.; Gray, M. A.; Bertozzi, C. R.; Rabuka, D.; Bassik, M. C. CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity. Nat. Chem. Biol. 2019, 15(10),949-958.

370. Lim, H. C.; Sher, J. W.; Rodriguez-Rivera, F. P.; Fumeaux, C.; Bertozzi, C. R.; Bernhardt, T. G. Identification of new components of the RipC-FtsEX cell separation pathway of Corynebacterineae. PLoS Genet. 2019, 15(8),e1008284.

369. *Ooi, Y. S.; *Majzoub, K.; *Flynn, R. A.; Mata, M. A.; Diep, J.; Li, J. K.; van Buuren, N.; Rumachik, N.; Johnson, A. G.; Puschnik, A. S.; Marceau, C. D.; Mlera, L.; Grabowski, J. M.; Kirkegaard, K.; Bloom, M. E.; Sarnow, P.; Bertozzi, C. R.; Carette, J. E. An RNA-centric dissection of host complexes controlling flavivirus infection. Nat. Microbiol. 2019, 4(12),2369-2382.

368. *Choi, J.; *Wagner, L. J. S.; Timmermans, S. B. P. E.; Malaker, S. A.; Schumann, B.; Gray, M. A.; Debets, M. F.; Takashima, M.; Gehring, J.; Bertozzi, C. R. Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs. J. Am. Chem. Soc. 2019, 141(34),13442-13453.

367. *Möckl, L.; *Pedram, K.; Roy, A. R.; Krishnan, V.; Gustavsson, A. K.; Dorigo, O.; †Bertozzi, C. R.; †Moerner, W. E. Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx. Dev. Cell 2019, 50(1),57-72.e6.

366. *Shurer, C. R.; *Kuo, J. C.; *Roberts, L. M.; Gandhi, J. G.; Colville, M. J.; Enoki, T. A.; Pan, H.; Su, J.; Noble, J. M.; Hollander, M. J.; O'Donnell, J. P.; Yin, R.; Pedram, K.; Moeckl, L.; Kourkoutis, L. F.; Moerner, W. E.; Bertozzi, C. R.; Feigenson, G. W.; Reesink, H. L.; Paszek, M. J. Physical Principles of Membrane Shape Regulation by the Glycocalyx. Cell 2019, 177(7),1757-1770.e21.

365. Waldman, A. J.; Bertozzi, C. R. A Sugar Cloak of Invisibility. Biochemistry 2019, 14;58(19), 2385-2386.

364. Pluvinage, J. V.; Haney, M. S.; Smith, B. A. H.; Sun, J.; Iram, T.; Bonanno, L.; Li, L.; Lee, D. P.; Morgens, D. W.; Yang, A. C.; Shuken, S. R.; Gate, D.; Scott, M.; Khatri, P.; Luo, J.; Bertozzi, C. R.; Bassik, M. C.; Wyss-Coray, T. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature 2019, 568(7751),187-192.

363. *Malaker, S. A.; *Pedram, K.; Ferracane, M. J.; Bensing, B. A.; Krishnan, V.; Pett, C.; Yu, J.; Woods, E.C.; Kramer, J.R.; Westerlind, U.; Dorigo, O.; Bertozzi, C.R. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. PNAS 2019, 116(15),7278-7287.

362. *Appel, M. J.; *Meier, K. K.; Lafrance-Vanasse, J.; Lim, H.; Tsai, C. L.; Hedman, B.; Hodgson, K. O.; †Tainer, J. A.; †Solomon, E. I.; †Bertozzi, C.R. Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation. PNAS 2019, 116(12), 5370-5375.

361. Zhou, X.; Rodriguez-Rivera, F. P.; Lim, H. C.; Bell, J. C.; Bernhardt, T. G.; Bertozzi, C. R.; Theriot, J. A. Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum. Nat. Chem. Biol. 2019, 15(3),221-231.

360. Baranov, M. V.; Bianchi, F.; Schirmacher, A.; van Aart, M. A. C.; Maassen, S.; Muntjewerff, E. M.; Dingjan, I.; Ter Beest, M.; Verdoes, M.; Keyser, S. G. L.; Bertozzi, C. R.; Diederichsen, U.; van den Bogaart, G. The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation. iScience 2018, 11, 160-167.

359. Spiciarich, D. R.; Oh, S. T.; Foley, A.; Hughes, S. B.; Mauro, M. J.; Abdel-Wahab, O.; Press, R. D.; Viner, R.; Thompson, S. L.; Chen, Q.; Azadi, P.; Bertozzi, C. R.; Maxson, J. E. A novel germline variant in CSF3R reduces N-glycosylation and exerts potent oncogenic effects in leukemia. Cancer Res. 2018, 15;78(24), 6762-6770.

358. Walton, E. M.; Cronan, M. R.; Cambier, C. J.; Rossi, A.; Marass, M.; Foglia, M. D.; Brewer, W. J.; Poss, K. D.; Stainier, D. Y. R.; Bertozzi, C. R.; Tobin, D. M. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Host Microbe 2018, 24(4), 514-525.

357. *Barnes, J. M.; *Kaushik, S.; Bainer, R. O.; Sa, J. K.; Woods, E. C.; Kai, F.; Przybyla, L.; Lee, M.; Lee, H. W.; Tung, J. C.; Maller, O.; Barrett, A. S.; Lu, K. V.; Lakins, J. N.; Hansen, K. C.; Obernier, K.; Alvarez-Buylla, A.; Bergers, G.; Phillips, J. J.; Nam, D. H.; Bertozzi, C. R.; Weaver, V. M. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat. Cell Biol. 2018, 20(10), 1203-1214.

356. Wan, S. J.; Sullivan, A. B.; Shieh, P.; Metruccio, M. M. E.; Evans, D. J.; Bertozzi, C. R.; Fleiszig, S. M. J. IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea. Front Microbiol. 2018, 29(9), 1117.

355. Yang, A. C.; du Bois, H.; Olsson, N.; Gate, D.; Lehallier, B.; Berdnik, D.; Brewer, K. D.; Bertozzi, C. R.; Elias, J. E.; Wyss-Coray, T. Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics. J. Am. Chem. Soc 2018, 140(23), 7046-7051.

354. Keyser, S. G. L.; Utz, A.; Bertozzi, C. R. Computation-guided rational design of a peptide motif that reacts with cyanobenzothiazoles via internal cysteine-lysine relay. J. Org. Chem. 2018, 20;83(14), 7467-7479.

353. Tomlin, F. M.; Gordon, C. G.; Han, Y.; Wu, T. S.; Sletten, E. M.; Bertozzi, C. R. Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct. Bioorganic and Med. Chem. 2018, 15;26(19), 5280-5290.

352. *Kamariza, M.; *Shieh, P.; Ealand, C. S.; Peters, J. S.; Chu, B.; Rodriguez-Rivera, F. P.; Babu Sait, M. R.; Treuren, W. V.; Martinson, N.; Kalscheuer, R.; Kana, B. D.; Bertozzi, C. R. Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe. Sci. Transl. Med. 2018, 10(430), eaam6310. [Download PDF]

351. Aebersold, R.; Agar, J. N.; Amster, I. J.; Baker, M. S.; Bertozzi, C. R.; et al. How many human proteoforms are there? Nat. Chem. Bio. 2018, 14(3), 206-214.

350. Rodriguez-Rivera, F. P.; Zhou, X.; Theriot, J. A.; Bertozzi, C. R. Acute modulation of mycobacterial cell envelope biogenesis by front-line TB drugs. Angew. Chem. Int. Ed. Engl. 2018, 57(19), 5267-5272.

349. *Zhou, M.; *Delaveris, C. S.; Kramer, J. R.; Kenkel, J. A.; Engleman, E. G.; Bertozzi, C. R. N-carboxyanhydride polymerization of glycopolypeptides that activate antigen presenting cells through Dectin-1 and -2. Angew Chem Int Ed Engl. 2018, 57(12), 3137-3142.

348. *Tsai, C. T.; *Robinson, P. V.; Cortez, F. J.; Elma, M. L. B.; Seftel, D.; Pourmandi, N.; †Pandori, M. W.; †Bertozzi, C. R. Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis. Proc Natl Acad Sci U.S.A. 2018, 115(6), 1250-1255.

347. Woo, C.M.; Lund, P.J.; Huang, A. C.; Davis, M. M.; Bertozzi, C. R.; Pitteri, S. Mapping and quantification of over 2,000 O-linked glycopeptides in activated human T cells with isotope-targeted glycoproteomics (IsoTaG). Mol Cell Proteomics. 2018, 17(4), 764-775.

346. Freeman, S. A.; Vega, A.; Riedl, M.; Collins, R. F.; Ostrowski, P. P.; Woods, E. C.; Bertozzi, C. R.; Tammi, M. I.; Lidke, D. S.; Johnson, P.; Mayor, S.; Jaqaman, K.; Grinstein, S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018, 172, 305-317.

345. Kamariza, M.; Shieh, P.; Bertozzi, C. R. Imaging Mycobacterial Trehalose Glycolipids. Methods Enzymol. 2018, 598, 355-369.

344. Woods, E. C.; Kai, F.; Barnes, J.M.; Pedram, K.; Pickup, M. W.; Hollander, M.J.; Weaver, V. M.; Bertozzi, C. R. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 2017, 6:e25752.

343. *Tsai, C. T.; *Mukai, K.; Robinson, P. V.; Gray, M. A.; Waschmann, M. B.; Lyu, S. C.; Tsai, M.; Chinthrajah, R. S.; Nadeau, K. C.; †Bertozzi, C. R.; †Galli, S. J. Isotype-Specific Agglutination-PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE. J. Allergy Clin. Immunol. 2018, 141(5), 1901-1904.e15.

342. *Tomlin, F. M.; *Gerling-Driessen, U. I. M.; Liu, Y-C; Flynn, R. A.; Vangala, J. R.; Lentz, C. S.; Clauder-Muenster, S.; Jakob, P.; Mueller, W. F.; Ordoñez-Rueda, D.; Paulsen, M.; Matsui, N.; Foley, D.; Rafalko, A.; Suzuki, T.; Bogyo, M.; Steinmetz, L. M.; Radhakrishnan, S. K.; Bertozzi, C. R. Inhibition of NGLY1 onactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity. ACS Central 2017, 3, 1143-1155.

342. Spiciarich, D. R.; Nolley, R.; Maund, S. L.; Purcell, S. C.; Herschel, J.; Iavarone, A. T.; Peehl, D. M.; Bertozzi, C. R. Bioorthogonal labeling of human prostate cancer tissue slice cultures for glycoproteomics. Angew. Chem. Int. Ed. Engl. 2017, 56, 8992-8997.

341. Hinderlich, S.; Tauber, R.; Bertozzi, C. R.; Hackenberger, C. P. R. Werner Reutter: A visionary pioneer in molecular glycobiology. Chembiochem. 2017, 18, 1141-1145.

340. Andres, L. M.; Blong, I. W.; Evans, A.C.; Rumachik, N. G.; Yamaguchi, T.; Pham, N. D.; Thompson, P.; Kohler, J. J.; Bertozzi, C. R. Chemical modulation of protein O-GlcNAcylation via OGT inhibition promotes human neural cell differentiation ACS Chem. Biol. 2017, 18, 2030-2039.

339. Woo, C. M.; Felix, A.; Byrd, W. E.; Zuegel, D. K.; Ishihara, M.; Azadi, P.; Iavarone, A. T.; Pitteri, S. J.; Bertozzi, C. R. Development of IsoTaG, a chemical glycoproteomics technique for profiling intact N- and O-glycopeptides from whole cell proteomes. J. Proteome Res. 2017, 16 1706–1718.

338. Jolly, A. L.; Agarwal, P.; Metruccio, M. M.; Spiciarich, D. R.; Evans, D. J.; Bertozzi, C. R.; Fleiszig, S. M. Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding. FASEB J. 2017, 31, 2393-2404.

337. Ganesan, L.; Shieh, P.; Bertozzi, C. R.; Levental, I.Click-chemistry based high throughput screening platform for modulators of Ras palmitoylation. Sci Rep. 2017, 7, 41147.

336. Rodriguez-Rivera, F. P.; Zhou, X,; Theriot, J. A. ; Bertozzi, C, R.Visualization of mycobacterial membrane dynamics in live cells. J. Am. Chem. Soc. 2017, 139, 3488-3495.

335. Schump, M. D.; Fox, D. M.; Bertozzi, C. R.; Riley, L. W. Subcellular partitioning and intra-macrophage selectivity of antimicrobial compounds against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 2017, 61, e01639-16.

334. Woo, C. M.; Felix, A.; Zhang, L.; Elias, J. E.; Bertozzi, C. R. Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars. Anal. Bioanal. Chem. 2017, 409, 579-588.

333. Palaniappan, K. K.; Bertozzi, C. R. Chemical glycoproteomics. Chem. Rev. 2016, 116, 14277-14306.

332. Sogi, K. M.; Holsclaw, C. M.; Fragiadakis, G. K.; Nomura, D. K.; Leary, J. A.; Bertozzi, C. R. Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis. ACS Infect. Dis. 2016, 2, 800-806.

331. Zhu, X.; Shieh, P.; Su, M.; Bertozzi, C. R.; Zhang, W. A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool. Chem. Commun. (Camb). 2016, 52, 11239-11242.

330. *Xiao, H.; *Woods, E. C.; Vukojicic, P.; Bertozzi, C. R. Precision glycocalyx editing as a strategy for cancer immunotherapy. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 10304-10309.

329. *Bhat, R.; *Belardi, B.; Mori, H.; Kuo, P.; Tam, A.; Hines, W. C.; Le, Q. T.; †Bertozzi, C. R.; †Bissell, M. J. Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 2016, 113, E4820-E4827.

328. *Robinson, P. V.; *Tsai, C. T.; de Groot, A. E.; McKechnie, J. L.; Bertozzi, C. R. Glyco-seek: Ultrasensitive detection of protein-specific glycosylation by proximity ligation polymerase chain reaction. J. Am. Chem. Soc. 2016, 138,, 10722-10725.

327. *Hudak, J. E.; *Belardi, B.; Appel, M. J.; Solania, A.; Robinson, P. V.; Bertozzi, C. R. Piperidine-based glycodendrons as protein N-glycan prosthetics. Bioorg. Med. Chem. 2016, S0968-0896, 30383-30292.

326. Ngo, J. T.; Adams, S. R.; Deerinck, T. J.; Boassa, D.; Rodriguez-Rivera, F.; Palida, S. F.; Bertozzi, C. R.; Ellisman, M. H.; Tsien, R. Y. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat. Chem. Bio. 2016, 12, 459–465.

325. Sheta, R.; Woo, C. M.; Roux-Dalvai, F.; Fournier, F.; Bourassa, S.; Droit, A.; Bertozzi, C. R.; Bachvarov, D. A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. J. Prot. 2016, 145, 91-102.

324. Lantos, A. B.; Carlevaro, G.; Araoz, B.; Ruiz Diaz, P.; Camara, Mde. L.; Buscaglia, C. A.; Bossi, M.; Yu, H.; Chen, X.; Bertozzi, C. R.; †Mucci, J.; †Campetella, O. Sialic acid glycobiology unveils Trypanosoma cruzi trypomastigote membrane physiology. PLoS Pathog. 2016, 12, e1005559.

323. Woo, C. M.; Bertozzi, C R. Isotope targeted glycoproteomics (IsoTaG) to characterize intact, metabolically labeled glycopeptides from complex proteomes. Curr. Protoc. Chem. Biol. 2016, 8, 59-82.

322. Tsai, C.; Robinson, P. V.; Spencer, C. A.; Bertozzi, C. R. Ultrasensitive antibody detection by agglutination-PCR (ADAP). ACS Cent. Sci. 2016, 2, 139-147.

321. Freeman, S. A.; Goyette, J.; Furuya, W.; Woods, E. C.; Bertozzi, C. R.; Bergmeier, W.; Hinz, B.; van der Merwe, P. A.; Das, R.; Grinstein, S. Integrins form an expanding diffusional barrier that coordinates phagocytosis. Cell 2016, 164, 128-140.

320. Woods, E. C.; Yee, N. A.; Shen, J.; Bertozzi, C. R. Glycocalyx engineering with a recycling glycopolymer that increases cell survival in vivo. Angew. Chem. Int. Ed. Engl. 2015, 54, 15782-15788.

319. Kim, J.; Bertozzi, C. R. A bioorthogonal reaction of N-oxide and boron reagents. Angew. Chem. Int. Ed. Engl. 2015, Available online.

318. Varki, A.; Cummings, R. D.; Aebi, M.; Packer, N. H.; Seeberger, P. H.; Esko, J. D.; Stanley, P.; Hart, G.; Darvill, A.; Kinoshita, T.; Prestegard, J. J.; Schnaar, R. L.; Freeze, H. H.; Marth, J. D.; Bertozzi, C. R.; Etzler, M. E.; Frank, M. Vliegenthart, J. F.; Lütteke, T.; Perez, S.; Bolton, E.; Rudd, P.; Paulson, J.; Kanehisa, M.; Toukach, P.; Aoki-Kinoshita, K. F.; Dell, A.; Narimatsu, H.; York, W.; Taniguchi, N.; Kornfeld, S. Symbol nomenclature for graphical representations of glycans. Glycobiology 2015, 25, 1323-1324.

317. Kramer, J. R.; Onoa, B.; Bustamante, C.; Bertozzi, C. R. Chemically tunable mucin chimeras assembled on living cells. Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 12574-12579.

316. Robinson, P. V.; de Almeida-Escobedo, G.; de Groot, A. E.; McKechnie, J. L.; Bertozzi, C. R. Live-cell labeling of specific protein glycoforms by proximity-enhanced bioorthogonal ligation. J. Am. Chem. Soc. 2015, 137, 10452-10455.

315. Belardi, B.; Bertozzi, C. R. Chemical lectinology: tools for probing the ligands and dynamics of mammalian lectins in vivo. Chem Biol. 2015, 15, 259-268.

314. *Agarwal, P.; *Beahm B. J.; Shieh, P.; Bertozzi, C. R. Systemic fluorescence imaging of zebrafish glycans with bioorthogonal chemistry. Angew. Chem. Int. Ed. Engl. 2015. 54, 11504-11510.

313. Tapia, H.; Young, L.; Fox, D.; Bertozzi, C. R.; Koshland, D. Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 2015, 16, 6122-6127.

312. Shieh, P.; Dien, V. T.; Beahm, B. J.; Castellano, J. M.; Wyss-Coray, T.; Bertozzi, C. R. CalFluors: A universal motif for fluorogenic azide probes across the visible spectrum. J. Am. Chem. Soc. 2015, 22, 7145-7151.

311. Woo, C. M.; Iavarone, A. T.; Spiciarich, D. R.; Palaniappan, K. K.; Bertozzi, C. R. Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis. Nat. Methods. 2015, 6, 561-567.

310. Siegrist, M. S.; Aditham, A.; Espaillat, A.; Cameron, T. A.; Whiteside, S.; Cava, F.; Portnoy, D. A.; Bertozzi, C. R. Host actin polymerization tunes the cell division cycle of an intracellular pathogen. Cell Rep. 2015, 4, 499-507.

309. Kuhn, J.; Götting, C.; Beahm. B. J.; Bertozzi, C. R.; Faust, I.; Kuzaj, P.; Knabbe. C.; Hendig, D. Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum. Biochem. Biophys. Res. Commun. 2015, 3, 469-74.

308. Siegrist, M. S.; Swarts, B. M.; Fox, D. M.; Lim, S. A.; Bertozzi, C. R. Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface. FEMS Microbiol. Rev. 2015, 39,184-202.

307. Appel, M. J.; Bertozzi, C. R. Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications. ACS Chem. Biol. 2015, 10, 72-84.

306. Agarwal, P.; Bertozzi, C. R. Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug. Chem. 2014. 16, 176-192.

305. Touchette, M. H.; Holsclaw, C. M.; Previti, M. L.; Solomon, V. C.; Leary, J. A.; Bertozzi, C. R.; Seeliger, J. C. The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J Bacteriol. 2014.1m 201-10.

304. Shieh, P.; Bertozzi, C. R. Design strategies for bioorthogonal smart probes. Org. Biomol. Chem. 2014, 12, 9307-9320.

303. Meniche, X.; Otten, R.; Siegrist, M. S.; Baer, C. E.; Murphy, K. C.; Bertozzi, C. R.; Sassetti, C. M. Subpolar addition of new cell wall is directed by DivIVA in mycobacteria. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, E3243–E3251.

302. Paszek, M. J.; DuFort, C. C.; Rossier, O.; Bainer, R.; Mouw, J. K.; Godula, K.; Hudak, J. E.; Lakins, J. N.; Wijekoon, A. C.; Cassereau, L.; Rubashkin, M. G.; Magbanua, M. J.; Thorn, K. S.; Davidson, M. W.; Rugo, H. S.; Park, J. W.; Hammer, D. A.; Giannone, G.; Bertozzi, C. R.; Weaver, V. M. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature 2014, 511, 319-325.

301. Smith, E. L.; Bertozzi, C. R.; Beatty, K. E. An Expanded Set of Fluorogenic Sulfatase Activity Probes. Chembiochem. 2014, 15, 1101-1105.

300. Shieh, P.; Siegrist, M. S.; Cullen, A. J.; Bertozzi, C. R. Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 5456-5461.

299. Beahm, B. J.; Bertozzi, C. R. "Imaging Cell-Surface Glycans in Animals with Bioorthogonal Chemistry." Glycoscience: Biology and Medicine. Ed. Endo, T.; Seeberger, P. H.; Hart, G. W.; Wong, C-H.; Taniguchi, T. Japan: Springer, 2014.1-11.

298. Smith, E. L.; Giddens, J. P.; Iavarone, A. T.; Godula, K.; Wang, L. X.; Bertozzi, C. R. Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags. Bioconjug. Chem. 2014, 25,788-795.

297. Sletten, E. M.; de Almeida, G.; Bertozzi, C. R. A Homologation Approach to the Synthesis of Difluorinated Cycloalkynes. Org. Lett. 2014, 16, 1634-1637.

296. Beahm, B. J.; Dehnert, K. W.; Derr, N. L.; Kuhn, J.; Eberhart, J. K.; Spillmann, D,; Amacher, S. L.; Bertozzi, C. R. A Visualizable Chain-Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish. Angew. Chem. Int. Ed. Engl. 2014, 53, 3347-3352.

295. Siegrist, M. S.; Bertozzi, C. R. Mycobacterial lipid logic. Cell Host Microbe. 2014, 15, 1-2.

294. *Hudak, J. E.; *Canham, S. M.; Bertozzi, C. R. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nature Chem. Biol. 2014, 10, 69-75.

293. Hatzios, S. K.; Baer, C. E.; Rustad, T. R.; Siegrist, M. S.; Pang, J. M.; Ortega, C.; Alber, T.; Grundner, C.; Sherman, D. R.; Bertozzi, C. R. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, E5069-E5077.

292. Hudak, J. E.; Bertozzi, C. R. Glycotherapy: New Advances Inspire a Reemergence of Glycans in Medicine. Chem. Biol. 2013, 21, 16-37.

291. Belardi, B.; de la Zerda, A.; Spiciarich, D. R.; Maund, S. L; Peehl, D. M.; Bertozzi, C. R. Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy. Angew. Chem. Int. Ed. Engl. 2013, 52, 14045-14049.

290. Bertozzi, C. R.; Wu, P. In vivo chemistry. Curr. Opin. Chem, Biol. 2013, 17, 717-718.

289. Palaniappan, K. K.; Hangauer, M. J.; Smith, T. J.; Smart, B. P.; Pitcher, A. A.; Cheng, E. H.; Bertozzi, C. R.; Boyce, M. A Chemical Glycoproteomics Platform Reveals O-GlcNAcylation of Mitochondrial Voltage-Dependent Anion Channel 2. Cell Rep. 2013, 5, 546-52.

288. Mauris, J.; Mantelli, F.; Woodward, A. M.; Cao, Z.; Bertozzi, C. R.; Panjwani, N.; Godula, K.; Argüeso, P. Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers. PLoS One 2013, 8, e72304.

287. Beatty, K. E.; Williams, M.; Carlson, B. L.; Swarts, B. M.; Warren, R. M.; van Helden, P. D.; Bertozzi, C. R. Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 12911-12916.

286. Sogi, K. M.; Gartner, Z. J.; Breidenbach, M. A.; Appel, M. J.; Schelle, M. W.; Bertozzi, C. R. Mycobacterium tuberculosis Rv3406 Is a Type II Alkyl Sulfatase Capable of Sulfate Scavenging. PLoS One 2013, 6, e65080.

285. Almeida, G. D.; Townsend, L. C.; Bertozzi, C. R. Synthesis and Reactivity of Dibenzoselenacycloheptynes. Org. Lett. 2013. Available ahead of print.

284. Shin, S. H.; Comolli, L, R.; Tscheliessnig, R.; Wang, C.; Nam, K. T.; Hexemer, A.; Siegerist, C. E.; De Yoreo, J. J.; Bertozzi, C. R. Self-Assembly of “S-Bilayers”, a Step Toward Expanding the Dimensionality of S-Layer Assemblies. A. C. S. Nano. 2013, 7, 4946-4953.

283. Comolli, L. R.; Siegerist, C. E.; Shin, S. H.; Bertozzi, C.; Regan, W.; Zettl, A.; De Yoreo, J. Conformational transitions at an S-layer growing boundary resolved by cryo-TEM. Angew. Chem. Int. Ed. Engl. 2013, 52, 4829-4832.

282. Van de Bittner, G. C.; Bertozzi, C. R.; Chang C. J. Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation. J. Am. Chem. Soc. 2013, 135, 1783-1795.

281. Siegrist, M. S.; Whiteside, S.; Jewett, J. C.; Aditham, A.; Cava, F.; Bertozzi, C. R. D-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen. ACS Chem. Biol. 2013. 8, 500-505.

280. Agarwal, P.; van der Weijden, J.; Sletten, E. M.; Rabuka, D.; Bertozzi, C. R. A Pictet-Spengler ligation for protein chemical modification. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 46-51.

279. *Shieh, P.; *Hangauer, M. J.; Bertozzi, C. R. Fluorogenic Azidofluoresceins for Biological Imaging. J. Am. Chem. Soc. 2012, 134, 17428-17431.

278. Swarts, B. M.; Holsclaw, C. M.; Jewett, J. C.; Alber, M.; Fox, D. M.; Siegrist, M. S.; Leary, J. A.; Kalscheuer, R.; Bertozzi, C. R. Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry. J. Am. Chem. Soc. 2012, 134, 16123-16126.

277. Godula, K.; Bertozzi, C. R. Density Variant Glycan Microarray for Evaluating Cross-Linking of Mucin-like Glycoconjugates by Lectins. J. Am. Chem. Soc. 2012, 134, 15732-15742.

276. Henkin, A. H.; Cohen, A. S.; Dubikovskaya, E. A.; Park, H. M.; Nikitin, G. F.; Auzias, M. G.; Kazantzis, M.; Bertozzi, C. R.; Stahl, A. Real time non-invasive imaging of fatty acid uptake in vivo. A. C. S. Chem. Bio. 2012, 7 1884-1891.

275. *Shin, S. H.; *Chung S.; Sanii, B.; Comolli, L. R.; †Bertozzi, C. R.; †De Yoreo, J. J. Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 12968-12973.

274. Chang, P. V.; Bertozzi, C. R. Imaging beyond the proteome. Chem. Commun. (Camb). 2012. 48, 8864-8879.

273. Rabuka, D.; Rush, J. S.; deHart, G. W.; Wu, P.; Bertozzi, C. R.; Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat. Protoc. 2012, 5, 1052-1067.

272. Gordon, C. G.; Mackey, J. L.; Jewett, J. C.; Sletten, E. M.; †Houk, K. N.; †Bertozzi, C. R.; Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry. J. Am. Chem. Soc. 2012, 134, 9199-9208.

271. Belardi, B.; O'Donoghue, G. P.; Smith, A. W.; Groves, J. T.; Bertozzi, C. R. Investigating Cell Surface Galectin-Mediated Cross-linking on Glycoengineered Cells. J. Am. Chem. Soc. 2012, 134, 9549-9552.

270. Onoe, H.; Hsiao, S. C.; Douglas, E. S.; Gartner, Z. J.; Bertozzi, C. R.; Francis, M. B.; Mathies, R. A. Cellular Microfabrication: Observing Intercellular Interactions Using Lithographically-Defined DNA Capture Sequences. Langmuir 2012, 28, 8120-8126.

269. Yu, S. H.; Boyce, M.; Wands, A. M.; Bond, M. R.; Bertozzi, C. R.; Kohler, J. J. Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 4834-4839.

268. Hudak, J. E.; Barfield, R. M.; de Hart, G.W.; Grob, P.; Nogales, E.; Bertozzi, C.R.; Rabuka, D. Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag.. Angew Chem Int Ed Engl. 2012, 51, 4161-4165.

267. *Griffin, J. E.; *Pandey, A. K.; Gilmore, S. A.; Mizrahi, V.; McKinney, J. D.; Bertozzi, C. R.; Sassetti C.M. Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations. Chem Biol. 2012, 19, 218-227.

266. Gilmore, S. A.; Schelle, M. W.; Holsclaw, C. M.; Leigh, C. D.; Jain, M.; Cox, J. S.; Leary, J. A.; Bertozzi, C. R. Sulfolipid-1 Biosynthesis Restricts Mycobacterium tuberculosis Growth in Human Macrophages. ACS Chem Biol. 2012, 7, 863-870.

265. de Almeida, G.; Sletten, E. M.; Nakamura, H.; Palaniappan, K. K.; Bertozzi, C. R. Thiacycloalkynes for Copper-Free Click Chemistry. Angew Chem Int Ed Engl. 2012, 51, 2443-2447.

264. Seeliger, J. C.; Topp, S.; Sogi, K. M.; Previti, M. L.; Gallivan, J. P.; Bertozzi, C. R. A riboswitch-based inducible gene expression system for mycobacteria.. PLoS One. 2012, 7, e29266.

263. Dehnert, K. W.; Baskin, J. M.; Laughlin, S. T.; Beahm, B. J.; Naidu, N. N.; Amacher, S. L.; Bertozzi, C. R. Imaging the Sialome during Zebrafish Development with Copper-Free Click Chemistry. Chembiochem. 2012, 13, 353-357.

262. *Breidenbach, M. A.; *Palaniappan, K. K.; Pitcher, A. A.; Bertozzi, C. R. Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics. 2012, 11, M111.015339.

261. Yao, J. Z.; Uttamapinant, C.; Poloukhtine, A. A.; Baskin, J. M.; Codelli, J. A.; Sletten, E. M.; Bertozzi, C. R.; Popik, V. V.; Ting, A. Y. Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc. 2012, 134, 3720-3728.

260. *An, H. J.; *Gip, P.; Kim, J.; Wu, S.; Park, K. W.; McVaugh, C. T.; †Schaffer, D. V.; †Bertozzi, C. R.; †Lebirlla, C. B. Extensive Determination of Glycan Heterogeneity Reveals an Unusual Abundance of High-Mannose Glycans in Enriched Plasma Membranes of Human Embryonic Stem Cells Mol Cell Proteomics. 2012, 11, M111.010660.

259. Seeliger, J. C.; Holsclaw, C. M.; Schelle, M. W.; Botyanszki, Z.; Gilmore, S. A.; Tully, S. E.; Niederweis, M.; Cravatt, B. F.; Leary, J. A.; Bertozzi, C. R. Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2012, 287, 7990-8000.

258. Jewett, J. C.; Bertozzi, C. R. Synthesis of a Fluorogenic Cyclooctyne Activated by Cu-Free Click Chemistry. Org Lett. 2011, 13, 5937-5939.

257. Bertozzi, C. R. A decade of bioorthogonal chemistry. Acc. Chem. Res 2011, 44, 651-653.

256. Sletten, E. M.; Bertozzi, C. R. A bioorthogonal quadricyclane ligation. J. Am. Chem. Soc. 2011, 133, 17570-17573.

255. Hudak, J. E.; Yu H. H.; Bertozzi, C. R. Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag. J. Am. Chem. Soc. 2011, 40, 16127-35.

254. Sletten, E. M.; Bertozzi, C. R. From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions. Acc Chem Res. 2011, 44, 666-676.

253. Boyce, M.; Bertozzi, C. R. Bringing chemistry to life. Nat Methods. 2011, 8, 638-642.

252. Hatzios, S. K.; Bertozzi, C. R. The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis. PLoS Pathog. 2011, 7,e1002036.

251. Hatzios, S. K.; Schelle, M. W.; Newton, G. L.; Sogi, K. M.; Holsclaw, C. M.; Fahey, R. C.; Bertozzi, C. R. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011, 21, 4945-4950.

250. Hubbard, S. C.; Boyce M.; McVaugh, C. T.; Peehl, D. M.; Bertozzi, C. R. Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. Bioorg Med Chem Lett. 2011, 21, 4945-4950.

249. *Palaniappan, K. K.; *Pitcher, A. A.; *Smart, B. P.; Spiciarich, D. R.; Iavarone, A. T.; Bertozzi, C. R. Isotopic signature transfer and mass pattern prediction (IsoStamp): An enabling technique for chemically-directed proteomics. ACS Chem. Biol. 2011, 6, 829-836.

248. Dehnert, K. W.; Beahm, B. J.; Huynh, T. T.; Baskin, J. M.; Laughlin, S. T.; Wang, W.; Wu, P.; Amacher, S. L.; Bertozzi, C. R. Metabolic labeling of fucosylated glycans in developing zebrafish. ACS Chem. Biol. 2011, 6, 547-552.

247. Boyce, M.; Carrico, I. S.; Ganguli, A. S.; Yu, S.-H.; Hangauer, M. J.; Hubbard, S. C.; Kohler, J. J.; Bertozzi, C. R. Metabolic cross-talk allows labeling of O-linked ß-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 3141-3146.

246. Shui, W.; Petzold, C. J.; Redding, A.; Liu, J.; Pitcher, A.; Sheu, L.; Hsieh, T.; Keasling, J. D.; Bertozzi, C. R. Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation. J. Proteome Res. 2011, 10, 339-348.

245. Binda, O.; Boyce, M.; Rush, J. S.; Palaniappan, K. K.; Bertozzi, C. R.; Gozani, O. A chemical method for labeling lysine methyltransferase substrates. ChemBioChem 2011, 12, 330-334.

244. Jasti, R.; Bertozzi, C. R. Progress and challenges for the bottom-up synthesis of carbon nanotubes with discrete chirality. Chem. Phys. Lett. 2010, 494, 1-7.

243. Van de Bittner, G. C.; Dubikovskaya, E. A.; Bertozzi, C. R.; Chang, C. J. In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 21316-21321.

242. Topp, S.; Reynoso, C. M.; Seeliger, J. C.; Goldlust, I. S.; Desai, S. K.; Murat, D.; Shen, A.; Puri, A. W.; Komeili, A.; Bertozzi, C. R.; Scott, J. R.; Gallivan, J. P. Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl. Environ. Microbiol. 2010, 76, 7881-7884.

241. Rush, J. S.; Beatty, K. E.; Bertozzi, C. R. Bioluminescent probes of sulfatase activity. ChemBioChem 2010, 15, 2096-2099.

240. Beatty, K. E.; Fisk, J. D.; Smart, B. P.; Lu, Y. Y.; Szychowski, J.; Hangauer, M. J.; Baskin, J. M.; Bertozzi, C. R.; Tirrell, D. A. Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. ChemBioChem 2010, 15, 2092-2095.

239. Chung, S.; Shin, S.-H.; Bertozzi, C. R.; De Yoreo, J. J. Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 16536-16541.

238. Sletten, E. M.; Nakamura, H.; Jewett, J. C.; Bertozzi, C. R. Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J. Am. Chem. Soc. 2010, 132, 11799-11805.

237. Godula, K.; Bertozzi, C. R. Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold. J. Am. Chem. Soc. 2010, 132, 9963-9965.

236. Chang, P. V.; Dube, D. H.; Sletten, E. M.; Bertozzi, C. R. A strategy for the selective imaging of glycans using caged metabolic precursors. J. Am. Chem. Soc. 2010, 132, 9516-9518.

235. Baskin, J. M.; Bertozzi, C. R. Copper-free click chemistry: bioorthogonal reagents for tagging azides. Aldrichimica Acta 2010, 43, 15-23.

234. Cohen, A. S.; Dubikovskaya, E. A.; Rush, J. S.; Bertozzi, C. R. Real-time bioluminescence imaging of glycans on living cells. J. Am. Chem. Soc. 2010, 132, 8563-8565.

233. *Baskin, J. M.; *Dehnert, K. W.; *Laughlin, S. T.; Amacher, S. L.; Bertozzi, C. R. Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 10360-10365.

232. Muia, R. P.; Yu, H.; Prescher, J. A.; Hellman, U.; Chen, X.; Bertozzi, C. R.; Campetella, O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology 2010, 20, 833-842.

231. Jewett, J. C.; Bertozzi, C. R. Cu-free click cycloaddition reactions in chemical biology. Chem. Soc. Rev. 2010, 39, 1272-1279.

230. Jewett, J. C.; Sletten, E. M.; Bertozzi, C. R. Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J. Am. Chem. Soc. 2010, 132, 3688-3690.

229. Breidenbach, M. A.; Gallagher, J. E. G.; King, D. S.; Smart, B. P.; Wu, P.; Bertozzi, C. R. Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 3988-3993.

228. *Chang, P. V.; *Prescher, J. A.; Sletten, E. M.; Baskin, J. M.; Miller, I. A.; Agard, N. J.; Lo, A.; Bertozzi, C. R. Copper-free click chemistry in living animals. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 1821-1826.

227. *Yap, M. C.; *Kostiuk, M. A.; Martin, D. D.; Perinpanayagam, M. A.; Hak, P. C.; Siddam, A.; Majjigapu, J. R.; Rajaiah, G.; Keller, B. O.; Prescher, J. A.; Wu, P.; Bertozzi, C. R.; Falck, J. R.; Berthiaume, L. G. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J. Lipid Res. 2010, 51, 1566-1580.

226. Laughlin, S. T.; Bertozzi, C. R. In Vivo Imaging of Caenorhabditis elegans Glycans. ACS Chem. Biol. 2009, 4, 1068-1072.

225. Varki, A.; Cummings, R. D.; Esko, J. D.; Freeze, H. H.; Stanley, P.; Marth, J. D.; Bertozzi, C. R.; Hart, G. W.; Etzler, M. E. Symbol nomenclature for glycan representation. Proteomics 2009, 9, 5398-5399.

224. Sletten, E. M.; Bertozzi, C. R. Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality. Angew. Chem., Int. Ed. 2009, 48, 6974-6998.

223. Godula, K.; Umbel, M. L.; Rabuka, D.; Botyanszki, Z.; Bertozzi, C. R.; Parthasarathy, R. Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers. J. Am. Chem. Soc. 2009, 131, 10263-10268.

222. Drake, P. M.; Stock, C. M.; Nathan, J. K.; Gip, P.; Golden, K. P.; Weinhold, B.; Gerardy-Schahn, R.; Bertozzi, C. R. Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 11995-12000.

221. Douglas, E. S.; Hsiao, S. C.; Onoe, H.; Bertozzi, C. R.; Francis, M. B.; Mathies, R. A. DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array. Lab Chip 2009, 9, 2010-2015.

220. Hsiao, S.C.; Shum, B.J.; Onoe, H.; Douglas, E.S.; Gartner, Z.J.; Mathies, R.A.; Bertozzi, C.R.; Francis, M.B. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir 2009, 25, 6985-6991.

219. Godula, K.; Rabuka, D.; Nam, K.T.; Bertozzi, C.R. Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-Like Glycopolymers for Microarray Applications. Angew. Chem., Int. Ed. 2009, 48, 4973-4976.

218. Song, J.; Xu, J.; Filion, T.; Saiz, E.; Tomsia, A. P.; Lian, J. B.; Stein, G. S.; Ayers, D. C.; Bertozzi, C. R. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J. Biomed. Mater. Res. 2009, 89, 1098-1107.

217. Perrine, C. L.; Ganguli, A.; Wu, P.; Bertozzi, C. R.; Fritz, T. A.; Raman, J.; Tabak, L. A.; Gerken, T. A. The glycopeptdie preferring polypeptide-GalNAc transferase-10 (ppGalNAc T10), involved in mucin type-O-glycosylation, has a unique GalNAc-O-Ser/Thr binding site in its catalytic domain not found in ppGalNAc T1 or T2. J. Biol. Chem. 2009, 284, 20387-20397.

216. Nessen, M. A.; Kramer, G.; Back, J.; Baskin, J. M.; Smeenk, L. E.; Van Maarseveen, J.; de Koning, L. J.; de Jong, L.; Bertozzi, C.; Hiemstra, H.; de Koster, C. G. Selective Enrichment of Azide-Containing Peptides from Complex Mixtures. J. Proteome Res. 2009, 8, 3702-3711.

215. Chang, P. V.; Chen, X.; Smyrniotis, C.; Xenakis, A.; Hu, T.; Bertozzi, C. R.; Wu, P. Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars. Angew. Chem., Int. Ed. 2009, 48, 4030-4033. [Download PDF]

214. Agard, N. J.; Bertozzi, C. R. Chemical Approaches to Perturb, Profile, and Perceive Glycans. Acc. Chem. Res. 2009, 42, 788-797.

213. Hur, G. H.; Meier, J. L.; Baskin, J.; Codelli, J. A.; Bertozzi, C. R.; Marahiel, M. A.; Burkart, M. D. Crosslinking Studies of Protein-Protein Interactions in Nonribosomal Peptide Biosynthesis. Chem. Biol. 2009, 16, 372-381.

212. Harland, C. W.; Botyanszki, Z.; Rabuka, D.; Bertozzi, C. R.; Parthasarathy, R. Synthetic Trehalose Glycolipids Confer Dessication Resistance to Supported Lipid Monolayers. Langmuir 2009, 25, 5193-5198.

211. Barb, A. W.; Leavy, T. M.; Robins, L. I.; Guan, Z.; Six, D. A.; Zhou, P.; Bertozzi, C. R.; Raetz, C. R. Uridine-Based Inhibitors as New Leads for Antibiotics Targeting Escherichia coli LpxC. Biochemistry 2009, 48, 3068-3077.

210. Gartner, Z. J.; Bertozzi, C. R. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 4606-4610.

209. Hatzios, S. K.; Schelle, M. W.; Holsclaw, C. M.; Behrens, C. R.; Botyanszki, Z.; Lin, F. L.; Carlson, B. L.; Kumar, P.; Leary, J. A.; Bertozzi, C. R. PapA3 is an acyltransferase required for Polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 2009, 284, 12745-12751.

208. Wu, P.; Shui, W.; Carlson, B. L.; Hu, N.; Rabuka, D.; Lee, J.; Bertozzi, C. R. Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 3000-3005.

207. Chen, X.; Wu, P.; Rousseas, M.; Okawa, D.; Gartner, Z.; Zettl, A.; Bertozzi, C. R. Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells. J. Am. Chem. Soc. 2009, 131, 890-891.

206. Laughlin, S. T.; Bertozzi, C. R. Imaging the Glycome. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 12-17.

205. Wu, P.; Chen, X.; Hu, N.; Tam, U. C.; Blixt, O.; Zettl, A.; Bertozzi, C. R. Biocompatible carbon nanotubes generated by functionalization with glycodendrimers. Angew. Chem., Int. Ed. 2008, 47, 5022-5025. [Download PDF]

204. Toriello, N. M.; Douglas, E. S.; Thaitrong, N.; Hsiao, S. C.; Francis, M. B.; Bertozzi, C. R.; Mathies, R. A. Integrated Microfluidic Bioprocessor for Single-Cell Gene Expression Analysis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 20173-20178.

203. Shui, W.; Gilmore, S. A.; Sheu, L.; Liu, J.; †Keasling, J. D.; †Bertozzi, C. R. Quantitative Proteomic Profiling of Host-Pathogen Interactions: The Macrophage Response to Mycobacterium tuberculosis Lipids. J. Prot. Res. 2008, 8, 282-289.

202. Jasti, R.; Bhattacharjee, J.; Neaton, J. B.; Bertozzi, C. R. Synthesis, Characterization, and Theory of [9]-, [12]-, and [18]Cycloparaphenylene: Carbon Nanohoop Structures. J. Am. Chem. Soc. 2008, 130, 17646-17647.

201. Drake, P. M.; Nathan, J. K.; Stock, C. M.; Chang, P. V.; Muench, M. O.; Nakata, D.; Reader, J. R.; Gip, P.; Golden, K. P.; Weinhold, B.; Gerardy-Schahn, R.; Troy, F. A. 2nd, Bertozzi, C. R. Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J. Immunol. 2008, 181, 6850-6858.

200. Shui, W.; Sheu, L.; Liu, J.; Smart, B.; Petzold, C. J.; Hsieh, T. Y.; Pitcher, A.; Keasling, J. D.; Bertozzi, C. R. Membrane proteomics of phagosomes suggests a connection to autophagy. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 16952-16957.

199. Holsclaw, C. M.; Sogi, K. M.; Gilmore, S. A.; Schelle, M. W.; Leavell, M. D.; Bertozzi, C. R.; Leary, J. A. Structural Characterization of a Novel Sulfated Menaquinone produced by stf3 from Mycobacterium tuberculosis. ACS Chem. Biol. 2008, 3, 619-624.

198. Hsiao, S. C.; Crow, A. K.; Lam, W. A.; Bertozzi, C. R.; Fletcher, D. A.; Francis, M. B. DNA-Coated AFM Cantilevers for the Investigation of Cell Adhesion and the Patterning of Live Cells. Angew. Chem., Int. Ed. 2008, 120, 8601-8605.

197. Czlapinski, J. L.; Schelle, M. W.; Miller, L. W.; Laughlin, S. T.; Kohler, J. J.; Cornish, V. W.; Bertozzi, C. R. Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization. J. Am. Chem. Soc. 2008, 130, 13186-13187.

196. Rush, J. S.; Bertozzi, C. R. New Aldehyde Tag Sequences Identified by Screening Formylglycine Generating Enzymes in Vitro and in Vivo. J. Am. Chem. Soc. 2008, 130, 12240-12241.

195. Codelli, J. A.; Baskin, J. M.; Agard, N. J.; Bertozzi, C. R. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry. J. Am. Chem. Soc. 2008, 130, 11486-11493.

194. Johnson, J. A.; Baskin, J. M.; Bertozzi, C. R.; Koberstein, J. T.; Turro, N. J. Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers. Chem. Commun. 2008, 3064-3066.

193. Paulick, M. G.; Bertozzi, C. R. The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins. Biochemistry 2008, 47, 6991-7000.

192. Sletten, E. M.; Bertozzi, C. R. A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry. Org. Lett. 2008, 10, 3097-3099.

191. Hatzios, S. K.; Iavarone, A. T.; Bertozzi, C. R. Rv2131c from Mycobacterium tuberculosis Is a CysQ 3'-Phosphoadenosine-5'-phosphatase. Biochemistry 2008, 47, 5823-5831.

190. *Laughlin, S. T.; *Baskin, J. M.; Amacher, S. L.; Bertozzi, C. R. In vivo imaging of membrane-associated glycans in developing zebrafish. Science 2008, 320, 664-667.

189. Rabuka, D.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes. J. Am. Chem. Soc. 2008, 130, 5947-5953.

188. Harland, C. W.; Rabuka, D.; Bertozzi, C. R.; Parthasarathy, R. The Mycobacterium tuberculosis Virulence Factor Trehalose Dimycolate Imparts Desiccation Resistance to Model Mycobacterial Membranes. Biophys. J. 2008, 94, 4718-4724.

187. Carlson, B. L.; Ballister, E. R.; Skordalakes, E.; King, D. S.; Breidenbach, M. A.; Gilmore, S. A.; Berger, J. M.; Bertozzi, C. R. Function and structure of a prokaryotic formylglycine-generating enzyme. J. Biol. Chem. 2008, 283, 20117-20125.

186. Hangauer, M. J.; Bertozzi, C. R. A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew. Chem., Int. Ed. 2008, 47, 2394-2397.

185. Leigh, C. D.; Bertozzi, C. R. Synthetic Studies toward Mycobacterium tuberculosis Sulfolipid-I. J. Org. Chem. 2008, 73, 1008-1017.

184. Martin, D. D.; Vilas, G. L.; Prescher, J. A.; Rajaiah, G.; Falck, J. R.; Bertozzi, C. R.; Berthiaume, L. G. Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J. 2008, 22, 797-806.

183. *Kostiuk, M. A.; *Corvi, M. M.; Keller, B. O.; Plummer, G.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R.; Rajaiah, G.; Falck, J. R.; Berthiaume, L. G. Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J. 2008, 22, 721-732.

182. Bertozzi, C. R.; Schelle, M. W. Sulfated Metabolites from Mycobacterium tuberculosis: Sulfolipid-1 and Beyond. In The Mycobacterial Cell Envelope, D. Mamadou & J.-M. Reyrat, Editors. ASM Press (Washington, DC), 2008.

181. Baskin, J. M.; Bertozzi, C. R. Bioorthogonal Click Chemistry: Covalent Labeling in Living Systems. QSAR Comb. Sci. 2007, 26, 1211-1219.

180. Paulick, M. G.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 20332-20337.

179. Fernandez-Suarez, M.; Baruah, H.; Martinez-Hernandez, L.; Xie, K. T.; Baskin, J. M.; Bertozzi, C. R.; Ting, A. Y. Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat. Biotechnol. 2007, 25, 1483-1487.

178. Douglas, E. S.; Chandra, R. A.; Bertozzi, C. R.; Mathies, R. A.; Francis, M. B. Self-assembled cellular microarrays patterned using DNA barcodes. Lab Chip 2007, 7, 1442-1448.

177. Parthasarathy, R.; Rabuka, D.; Bertozzi, C. R.; Groves, J. T. Molecular orientation of membrane-anchored mucin glycoprotein mimics. J. Phys. Chem. B. 2007, 111, 12133-12135.

176. Baskin, J. M.; Prescher, J. A.; Laughlin, S. T.; Agard, N. J.; Chang, P. V.; Miller, I. A.; Lo, A.; Codelli, J. A.; Bertozzi, C. R. Copper-free click chemistry for dynamic in vivo imaging. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 16793-16797.

175. Paulick, M. G.; Wise, A. R.; Forstner, M. B.; Groves, J. T.; Bertozzi, C. R. Synthetic analogues of glycosylphosphatidylinositol-anchored proteins and their behavior in supported lipid bilayers. J. Am. Chem. Soc. 2007, 129, 11543-11550.

174. Laughlin, S. T.; Bertozzi, C. R. Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation. Nat. Protoc. 2007, 2, 2930-2944.

173. Lin, F. L.; van Halbeek, H.; Bertozzi, C. R.  Synthesis of Mono- and Dideoxygenated a,a-Trehalose Analogs.  Carbohydr. Res. 2007, 342, 2014-2030.

172. Chang. P. V.; Prescher, J. A.; Hangauer, M. J.; Bertozzi, C. R.  Imaging Cell Surface Glycans with Bioorthogonal Chemical Reporters.  J. Am. Chem. Soc. 2007, 129, 8400-8401.

171. *Kumar, P.; *Schelle, M. W.; Jain, M.; Lin, F. L.; Petzold, C. J.; Leavell, M. D.; Leary, J. A.; Cox, J. S.; Bertozzi, C. R.  PapA1 and PapA2 are Acyltransferases Essential for the Biosynthesis of the Mycobacterium tuberculosis Virulence Factor Sulfolipid-1.  Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 11221-11226.

170. Leavy, T. L.; Bertozzi, C. R.  A High-Throughput Assay for O-GlcNAc Transferase Detects Primary Sequence Preferences in Peptide Substrates. Bioorg. Med. Chem. Lett. 2007, 7, 3851-3854.

169. Rabuka, D.; Parthasarathy, R.; Lee, G. S.; Chen, X.; Groves, J. T.; Bertozzi, C. R. Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers. J. Am. Chem. Soc. 2007, 129, 5462-5471.

168. *Carrico, I. S.; *Carlson, B. L.; Bertozzi, C. R. Introducing Genetically Encoded Aldehydes into Proteins.  Nature Chem. Biol. 2007, 3, 321-322.

167. Jain, M; Petzold, C.J.; Schelle, M.W.; Leavell, M.D.; Mougous, J.D.; Bertozzi, C.R.; Leary, J.A.; Cox, J.S. Lipidomics Reveals Control of Mycobacterium tuberculosis Virulence Lipids via Metabolic Coupling. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 5133-5138.

166. Chen, X.; Kis, A.; Zettl, Z.; Bertozzi, C. R. A Cell Nanoinjector Based on Carbon Nanotubes. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 8218-8222.

165. Senaratne, R. H.; Mougous, J. D.; Reader, J. R.; Williams, S. J.; Zhang, T.; Bertozzi, C. R.; Riley, L. W.  Vaccine Efficacy of Attenuated but Persistent Mycobacterium tuberculosis cysH Mutant. J. Med. Microbiol. 2007, 56, 454-458.

164. Gao, H.; Leary, J.; Carroll, K. S.; Bertozzi, C. R.; Chen, H. Noncovalent Complexes of APS Reductase from M. tuberculosis: Delineating a Mechanistic Model Using ESI-FTICR MS.  J. Am. Soc. Mass Spectrom. 2007, 18, 167-178.

163. Laughlin, S. T.; Agard, N. J.; Baskin, J. M.; Carrico, I. S.; Chang, P. V.; Ganguli, A. S.; Hangauer, M. J.; Lo, A.; Prescher, J. A.; Bertozzi, C. R. Metabolic Labeling of Glycans with Azido Sugars for Visualization and Glycoproteomics.  Methods Enzymol. 2006, 415, 230-250.

162. Czlapinski, J. L.; Bertozzi, C. R.  Synthetic Glycobiology: Exploits in the Golgi Compartment.  Curr. Opin. Chem. Biol. 2006, 10, 645-51.

161. Agard, N. J.; Baskin, J. M.; Prescher, J. A.; Lo, A.; Bertozzi, C. R.  A Comparative Study of Bioorthogonal Reactions with Azides.  ACS Chem. Biol. 2006, 1, 644-8.

160. *Kehoe, J. W.; *Velappan, N.; Walbolt, M.; Rasmussen, J.; King, D.; Lou, J.; Knopp, K.; Pavlik, P.; Marks, J.; †Bertozzi, C. R.; †Bradbury, A. R. M.   Using Phage Display to Select Antibodies Recognizing Post-translational Modifications Independently of Sequence Context.  Mol. Cell. Proteomics 2006, 5, 2350-63.

159. Chartron, J.; Carroll, K. S.; Shiau, C.; Gao, H.; Leary, J. A.; Bertozzi, C. R.; Stout, C. D.  Substrate Recognition, Protein Dynamics, and Iron-Sulfur Cluster in Pseudomonas aeruginosa Adenosine 5’-Phosphosulfate Reductase.  J. Mol. Biol. 2006 364, 152-69.

158. Rabuka, D.; Hubbard, S. C.; Laughlin, S. T.; Argade, S. P.; Bertozzi, C. R.  A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation. J. Am. Chem. Soc. 2006, 128, 12078-9.

157. Schelle, M. W.; Bertozzi, C. R.  Sulfate Metabolism in Mycobacteria. ChemBioChem 2006, 7, 1516-24.

156. Prescher, J. A.; Bertozzi, C. R.  Chemical Technologies for Probing Glycans. Cell  2006, 126, 851-854.

155. Stowell, C. L.; Barvian, K. K.; Young, P. C.; Bigsby, R. M.; Verdugo, D. E.; Bertozzi, C. R.; Widlanski, T. S.  A Role for Sulfation-Desulfation in the Uptake of Bisphenol A Into Breast Tumor Cells.  Chem. Biol. 2006, 13, 891-897.

154. Link, A. J.; Vink, M. K.; Agard, N. J.; Prescher, J. A.; Bertozzi, C. R.; Tirrell, D. A.  Discovery of Aminoacyl-tRNA Synthetase Activity Through Cell Surface Display of Noncanonical Amino Acids.  Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 10180-5.

153. Chen, X.; Tam, U. C.; Czlapinski, J. L.; Lee, G. S.; Rabuka, D.; Zettl, A.; Bertozzi, C. R.  Interfacing Carbon Nanotubes with Living Cells.  J. Am. Chem. Soc. 2006, 128, 6292-3.

152. *Dube, D. H.; *Prescher, J. A.; Quang, C. N.; Bertozzi, C. R.  Probing Mucin-type O-linked Glycosylation in Living Animals.  Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4819-24.

151. Juan Perez-Vilar, Raean Mabolo, Cheryl T. McVaugh, Carolyn R. Bertozzi, and Richard C. Boucher. Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells. Roles of Protein Post-translational Modifications and Secretion. J. Biol. Chem. 2006, 281, 4844-55.

150. Senaratne, R. H.; DeSilva, D.; Williams, S. J.; Mougous, J. D.; Zhang, T.; Chan, S.; Sidders, B.; Chan, J.; Bertozzi, C. R.; W. Riley, L. W. 5’-Adenosinephosphosulphate Reductase (CysH) Protects Mycobacterium tuberculosis Against Free Radicals During Chronic Infection Phase in Mice. Mol. Microbiol. 2006, 59, 1744-53.

149. Mougous, J. D.; Senaratne, R. H.; Petzold, C. J.; Jain, M.; Lee, D. H.; Schelle, M. W.; Leavell, M. D.; Cox, J. S.; Leary, J. A.; Riley, L. W.; Bertozzi, C. R.  A Sulfated Metabolite Produced by stf3 Negatively Regulates the Virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4258-63.

148. Rush, J. S.; Bertozzi, C. R. An a-formylglycine building block for Fmoc-based solid phase peptide synthesis. Org. Lett. 2006, 8, 131-134.

147. Mougous, J. D.; Lee, D. H.; Hubbard, S. C.; Schelle, M. W.; Vocadlo, D. J.; Berger, J. M.; Bertozzi, C. R. Molecular Basis for G protein Control of ATP Sulfurylase in Bacteria. Molecular Cell 2006, 21, 109-122.

146. Chandra, R. A.; Douglas, E. S.; Mathies, R. A.; Bertozzi, C. R.; Francis, M. B. Programmable Cell Adhesion Encoded by DNA Hybridization.  Angew. Chem., Int. Ed. 2006, 45, 896-901.

145. *Carroll, K. S.; *Gao, H.; Chen, H.; Leary, J. A.; Bertozzi, C. R. Investigation of the Iron-Sulfur Cluster in Mycobacterium tuberculosis APS Reductase: Implications for Substrate Binding and Catalysis. Biochemistry 2005, 44, 14647-14657.

144. Tomsia, A. P.; Saiz, E.; Song, J.; Bertozzi, C. R. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005, 7, 999-1004.

143. Hang, H. C.; Bertozzi, C. R. The Chemistry and Biology of Mucin-Type O-Linked Glycosylation. Bioorg. Med. Chem. 2005, 13, 5021-5034.

142. Carroll, K. S.; Gao, H.; Chen, H.; Stout, C. D.; Leary, J. A.; Bertozzi, C. R. A Conserved Mechanism for Sulfonucleotide Reduction.  PloS Biology 2005, 3 (8), e250.

141. Grogan, M. J.; Kaizuka, Y.; Conrad, R. M.; Groves, J. T.; Bertozzi, C. R.  Synthesis of Lipidated Green Fluorescent Protein and its Incorporation in Supported Lipid Bilayers.  J. Am. Chem. Soc., 2005, 127, 14383-14387.

140. Prescher, J. A.; Bertozzi, C. R. Chemistry in Living Systems. Nature Chem. Biol. 2005, 1, 13-21.

139. Dube, D. H.; Bertozzi, C. R. Glycans in Cancer and Inflammation – Potential for Therapeutics and Diagnostics.  Nature Rev. Drug Disc. 2005, 4, 477-88.

138. Saad, O. M.; Ebel, H.; Uchimura, K.; Rosen, S. D.; Bertozzi, C. R.; Leary, J. A. Compositional Profiling of Heparin/Heparan Sulfate Using Mass Spectrometry: Assay for Specificity of a Novel Extracellular Human Endosulfatase.  Glycobiology 2005, 15, 818-826.

137. Pi, N.; Hoang, M. B.; Gao, H.; Mougous, J. D.; Bertozzi, C. R.; Leary, J. A. Kinetic Measurements and Mechanism Determination of Stf0 Sulfotransferase Using Mass Spectrometry.  Anal. Biochem. 2005, 341, 94-104.

136. Song, J.; Malathong, V.; Bertozzi, C. R. Mineralization of Synthetic Polymer Scaffolds: A Bottom-up Approach for the Development of Artificial Bone. J. Am. Chem. Soc. 2005, 127, 3366-3372.

135. Lin, F., Hoyt, H. M.; van Halbeek, H.; Bergman, R. G.; Bertozzi, C. R.  Mechanistic Investigation of the Staudinger Ligation.  J. Am. Chem. Soc. 2005, 127, 2686-2695.

134. Pratt, M. R.; Bertozzi, C. R. Synthetic Glycopeptides and Glycoproteins as Tools for Biology and as Therapeutic Agents.  Chem. Soc. Rev. 2005, 34, 58-68.

133. Samuel, J.; Bertozzi, C. R. Chemical Tools for the Study of Polysialic Acid. Trends in Glycoscience 2004, 91, 305-318.

132. Vocadlo, D. J.; Bertozzi, C. R. A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates.  Angew. Chem., Int. Ed. 2004, 43, 5338-5342.

131. Tian, E.; Ten Hagen, K. G.; Shum, L.; Hang, H. C.; Imbert, Y.; Young, W. W., Jr.; Bertozzi, C. R.; Tabak, L. A.  An Inhibitor of O-Glycosylation Induces Apoptosis in NIH3T3 Cells and Developing Mouse Embryonic Mandibular Tissues.  J. Biol. Chem. 2004, 279, 50382-50390.

130. Agard, N. J.; Prescher, J. A.; Bertozzi, C. R.  A Strain-Promoted [3+2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems.  J. Am. Chem. Soc. 2004, 126, 15046-15047.

129. Song, J.; Bertozzi, C. R. Functional Polymers for Bone Tissue Engineering Applications, In Handbook of Nanostructured Materials and Their Applications in Nanobiotechnology, H. S. Nalwa, Editor.  American Scientific Publishers, 2005. Vol 1, pp 1-22.

128. Chen, X.; Lee, G. S.; Zettl, A.; Bertozzi, C. R. Biomimetic Engineering of Carbon Nanotubes By Using Cell Surface Mimics.  Angew. Chem., Int. Ed. 2004, 43, 6112-6116.

127. Luchansky, S. J.; Argade, S.; Hayes, B. K.; Bertozzi, C. R. Metabolic Functionalization of Recombinant Glycoproteins. Biochemistry 2004, 43, 12358-12366.

126. *Prescher, J. A.; *Dube, D. H.; Bertozzi, C. R. Chemical Remodelling of Cell Surfaces in Living Animals. Nature 2004, 430, 873-877.

125. Luchansky, S. J.; Bertozzi, C. R. Azido Sialic Acids can Modulate Cell Surface Interactions. ChemBioChem 2004, 5, 1706-1709.

124. Kohler, J. J.; Czlapinski, J. L.; Laughlin, S. T.; Schelle, M. W.; de Graffenried, C. L.; Bertozzi, C. R. Directing Flux in Glycan Biosynthetic Pathways with a Small Molecule Switch. ChemBioChem 2004, 5, 1455-1458.

123. de Graffenried, C. L.; Laughlin, S. T.; Kohler, J. J.; Bertozzi, C. R. A Small-Molecule Switch for Golgi Sulfotransferases.  Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16715-16720.

122. de Graffenried, C. L.; Bertozzi, C. R. The Stem Region of the Sulfotransferase GlcNAc6ST-1 is a Determinant of Substrate Specificity.  J. Biol. Chem. 2004, 279, 40035-40043.

121. Song, J.; Chen, J.; Klapperich, C. M.; Eng, V.; Bertozzi, C. R. Functional Glass Slides for In Vitro Evaluation of Interactions Between Osteosarcoma TE85 Cells and Mineral-Binding Ligands.  J. Mat. Chem. 2004, 14, 2643-2648.

120. de Graffenried, C. L.; Bertozzi, C. R. The Roles of Enzyme Localisation and Complex Formation in Glycan Assembly within the Golgi Apparatus. Curr. Opin. Cell Biol. 2004, 16, 356-363.

119. Song, J.; Cisar, J. S.; Bertozzi, C. R. Functional Self-Assembling Bolaamphiphilic Polydiacetylenes as Colorimetric Sensor Scaffolds. J. Am. Chem. Soc. 2004, 126, 8459-8465.

118. Mougous, J. D.; Petzold, C. J.; Senaratne, R. H.; Lee, D. H.; Akey, D. L.; Lin, F. L.; Munchel, S. E.; Pratt, M. R.; Riley, L. W.; Leary, J. A.; Berger, J. M.; Bertozzi, C. R. Identification, Function and Structure of the Mycobacterial Sulfotransferase that Initiates Sulfolipid-1 Biosynthesis. Nature Struct. Mol. Biol. 2004, 11, 721-729.

117. Woodruff, P. J.; Carlson, B. L.; Siridechadilok, B.; Pratt, M. R.; Mougous, J. D.; Senaratne, R.; Riley, L. W.; Williams, S. J.; Bertozzi, C. R.  Trehalose is Required for Growth of Mycobacterium smegmatis.  J. Biol. Chem. 2004, 279, 28835-28843.

116. Pratt, M. R.; Bertozzi, C. R. Syntheses of 6-Sulfo Sialyl Lewis X Glycans Corresponding to the L-Selectin Ligand “Sulfoadhesin”. Org. Lett. 2004, 6, 345-2348.

115. Pratt, M. R.; Hang, H. C.; Ten Hagen, K. G.; Rarick, J.; Gerken, T. A.; Tabak, L. A.; Bertozzi, C. R.  Deconvoluting the Functions of Polypeptide N-a-Acetylgalactosaminyltransferase (ppGalNAcT) Family Members by Glycopeptide Substrate Profiling. Chem. Biol. 2004, 11, 1009-1016.

114. Klapperich, C. M.; Bertozzi, C. R. Global Gene Expression Patterns of Cells Attached to a Tissue Engineering Scaffold. Biomaterials 2004, 25, 5631-5641.

113. Macmillan, D.; Bertozzi, C. R. Modular Assembly of Glycoproteins: Toward the Synthesis of GlyCAM-1 by Using Expressed Protein Ligation.  Angew. Chem., Int. Ed. 2004, 43, 1355-1359.

112. Hang, H. C.; Yu, C.; Ten Hagen, K. G.; Tian, E.; Winans, K. A.; Tabak, L. A.; Bertozzi, C. R. Small Molecule Inhibitors of Mucin-type O-Linked Glycosylation from a Uridine-based Library. Chem. Biol. 2004, 11, 337-345.

111. Grossman,  H. L.; Myers, W. R.; Vreeland, V. J.; Bruehl, R.; Alper, M. D.; Bertozzi, C. R.; Clarke, J.  Detection of Bacteria in Suspension by Using a Superconducting Quantum Interference Device. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 129-134.

110. *Luchansky, S. J.; *Goon, S.; Bertozzi, C. R. Expanding the Diversity of Unnatural Cell Surface Sialic Acids. ChemBioChem 2004, 5, 371-374.

109. Hang, H. C.; Yu, C.; Pratt, M. R.; Bertozzi, C. R. Probing Glycosyltransferase Activities with the Staudinger Ligation. J. Am. Chem. Soc. 2004, 126, 6-7.

108. Hang, H. C.; Yu, C.; Kato, D. L.; Bertozzi, C. R. A Metabolic Labeling Approach Towards Proteomic Analysis of Mucin-type O-Linked Glycosylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 14846-14851.

107. Kohler, J. J.; Bertozzi, C. R. Regulating Cell Surface Glycosylation by Small Molecule Control of Enzyme Localization. Chem. Biol. 2003, 10, 1303-1311.

106. Verdugo, D. E.; Pedersen, L. C.; Bertozzi, C. R. Small Molecule Inhibitors of the Sulfotransferases, in Carbohydrate-Based Drug Discovery, Wong, C.-H., Ed. Wiley-VCH, 2003. pp 781-797.

105. Dube, D. H.; Bertozzi, C. R. Metabolic Oligosaccharide Engineering as a Tool for Glycobiology. Curr. Opin. Chem. Biol. 2003, 7, 616-625.

104. Wojczyk, B. S.; Stwora-Wojczyk, M. M.; Hagen, F. K.; Striepen, B.; Hang, H. C.; Bertozzi, C. R.; Roos, D. S.; Spitalnik, S. L. cDNA Cloning and Expression of UDP-N-acetyl-D-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase T1 from Toxoplasma gondii.  Mol. Biochem. Parasitol., 2003, 131, 93-107.

103. Pratt, M. R.; Leigh, C. D.; Bertozzi, C. R. Formation of 1,1-a,a-Glycosidic Bonds by Intramolecular Aglycone Delivery. A Convergent Synthesis of Trehalose. Org. Lett. 2003, 5, 3185-3188.

102. de Graffenried, C. L.; Bertozzi, C. R. Golgi Localization of Carbohydrate Sulfotransferases is a Determinant of L-Selectin Ligand Biosynthesis. J. Biol. Chem. 2003, 278, 40282-40295.

101. Song, J.; Saiz, E.; Bertozzi, C. R. Preparation of pHEMA-CP Composites with High Interfacial Adhesion via Template-Driven Mineralization. J. Eur. Ceramic Soc. 2003, 23, 2905-2919.

100. Vocadlo, D. J.; Hang, H. C.; Kim, E. J.; Hanover, J. A.; Bertozzi, C. R. A Chemical Approach for Identifying O-GlcNAc Modified Proteins in Cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 9116-9121.

99. Converse, S. E.; Mougous, J. M.; Leavell, M. D.; Leary, J. A.; Bertozzi, C. R.; Cox, J. S. MmpL8 is Required for Sulfolipid Biosynthesis and M. tuberculosis Virulence. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 6121-6126.

98. Pratt, M. R.; Bertozzi, C. R. Chemoselective Ligation Applied to the Synthesis of a Biantennary N-Linked Glycoform of CD52. J. Am. Chem. Soc. 2003, 125, 6149-6159.

97. Goon, S.; Schilling, B.; Tullius, M. V.; †Gibson, B. W.; †Bertozzi, C. R. Metabolic Incorporation of Unnatural Sialic Acids into Haemophilus ducreyi Lipooligosaccharides.  Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3089-3094.

96. Lemieux, G. A.; de Graffenried, C. L.; Bertozzi, C. R. A Fluorogenic Dye Activated by the Staudinger Ligation. J. Am. Chem. Soc. 2003, 128, 4708-4709.

95. Luchansky, S. J.; Yarema, K. J.; Bertozzi, C. R. GlcNAc 2-Epimerase Can Serve a Catabolic Role in Sialic Acid Metabolism. J. Biol. Chem. 2003, 278, 8035-8042.

94. Song, J.; Saiz, E.; Bertozzi, C. R. A New Approach to Mineralization of Biocompatible Hydrogel Scaffolds: An Efficient Process Toward 3-Dimensional Bonelike Composites. J. Am. Chem. Soc. 2003, 125, 1236-1243.

93. Marcaurelle, L. A.; Pratt, M. R.; Bertozzi, C. R. Synthesis of Thioether-Linked analogs of the 2,3-Sialyl-TF and MECA-79 Antigens: Mucin-Type Glycopeptides Associated with Cancer and Inflammation. ChemBioChem. 2003, No. 2-3, 224-228.

92. Luchansky, S. J.; Hang, H. C.; Saxon, E.; Grunwell, J. R.; Yu, C.; Dube, D. H.; Bertozzi, C. R. Constructing Azide-Labeled Cell Surfaces Using Polysaccharide Biosynthetic Pathways. Meth. Enzymol. 2003, 362, 249-272.

91. Scherman, M. S.; Winans, K. A.; Stern, R. J.; Jones, V.; Bertozzi, C. R.; McNeil, M. R. Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Development of a Microtiter Plate-Based Screen for UDP-galactopyranose Mutase and Identification of an Inhibitor from a Uridine-Based Library. Antimicrobial Agents and Chemotherapy 2003, 47, 378-382.

90. Armstrong, J. I.; Verdugo, D. E.; Bertozzi, C. R. Synthesis of a Bisubstrate Analog Targeting Estrogen Sulfotransferase. J. Org. Chem. 2003, 68, 170-173.

89. *Mougous, J. D.; *Leavell, M. D.; Senaratne, R. H.; Leigh, C. D.; Williams, S. J.; Riley, L. W.; †Leary, J. A.; †Bertozzi, C. R. Discovery of Sulfated Metabolites in Mycobacteria With a Genetic and Mass Spectrometric Approach. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 17037-17042.

88. Saxon, E.; Luchansky, S. J.; Hang, H. C.; Yu, C.; Lee, S. C.; Bertozzi, C. R. Investigating Cellular Metabolism of Synthetic Azidosugars Using the Staudinger Ligation. J. Am. Chem. Soc. 2002, 124, 14893-14902.

87. Grunwell, J. R.; Rath, V. L.; Rasmussen, J.; Cabrilo, Z.; Bertozzi, C. R. Characterization and Mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. Biochemistry 2002, 41, 15590-15600.

86. Grunwell, J. R.; Bertozzi, C. R. Carbohydrate Sulfotransferases of the GalNAc/Gal/GlcNAc6ST Family.  Biochemistry 2002, 41, 13117-13126.

85. *Parak, W. J.; *Gerion, D.; Zanchet, D.; Woerz, A. S.; Pellegrino, R.; Micheel, C.; Williams, S. C.; Seitz, M.; Bruehl, R. E.; Bryant, Z.; Bustamante, C.; Bertozzi, C. R.; Alivisatos, A. P. Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots. Chem. Mater. 2002, 14, 2113-2119.

84. Pi, N.; Armstrong, J. I.; Bertozzi, C. R.; Leary, J. A. Kinetic Analysis of NodST Sulfotransferase Using an Electrospray Ionization Mass Spectrometry Assay. Biochemistry 2002, 41, 13283-13288.

83. Mougous, J. D.; Green, R. E.; Williams, S. J.; Brenner, S. E.; Bertozzi, C. R. Sulfotransferases and Sulfatases in Mycobacteria. Chem. Biol. 2002, 9, 767-776.

82. Williams, S. J.; Senaratne, R. H.; Mougous, J. D.; Riley, L. W.; Bertozzi, C. R. 5’-Adenosinephosphosulfate Lies at a Metabolic Branchpoint in Mycobacteria. J. Biol. Chem. 2002, 277, 32606-32615.

81. Verdugo, D. E.; Bertozzi, C. R. A 96-Well Dot-Blot Assay for Carbohydrate Sulfotransferases. Anal. Biochem. 2002, 307, 330-336.

80. Grogan, M. J.; Pratt, M. R.; Marcaurelle, L. A.; Bertozzi, C. R. Homogeneous Glycopeptides and Glycoproteins for Biological Investigation. Annu. Rev. Biochem. 2002, 71, 593-634.

79. Conrad, R. M.; Grogan, M. J.; Bertozzi, C. R. Stereoselective Synthesis of myo-Inositol via Ring-Closing Metathesis: A Building Block for Glycosylphosphatidylinositol (GPI) Anchor Synthesis. Org. Lett. 2002, 4, 1359-1361.

78. Charter, N; Mahal, L. K.; Koshland, D. E., Jr.; Bertozzi, C. R. Differential Effects of Unnatural Sialic Acids on the Polysialylation of NCAM and Neuronal Behavior. J. Biol. Chem. 2002, 277, 9255-9261.

77. Winans, K. A.; Bertozzi, C. R. An Inhibitor of the Human UDP-GlcNAc 4-Epimerase Identified from a Uridine-Based Library: A Strategy to Inhibit O-Linked Glycosylation. Chem. Biol. 2002, 9, 113-129.

76. *Kiick, K. L.; *Saxon, E.; †Tirrell, D. A.; †Bertozzi, C. R. Incorporation of Azides into Recombinant Proteins for Chemoselective Modification by the Staudinger Ligation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 19-24.

75. Cook, B. N.; Bertozzi, C. R. Chemical Approaches to the Investigation of Cellular Systems. Bioorg. Med. Chem. 2002, 10, 829-840.

74. Marcaurelle, L. A.; Bertozzi, C. R. Recent Advances in the Chemical Synthesis of Mucin-Type Glycoproteins. Glycobiology 2002, 12, R69-R77.

73. Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Ouyang, Y.-B.; Moore, K. L.; Ellman, J. E.; Bertozzi, C. R.  Tyrosylprotein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided Ligand Assembly.  Bioorg. Med. Chem. Lett. 2002, 12, 329-332.

72. Nauman, D. A.; Bertozzi, C. R. Determination of Kinetic Parameters for Chemoselective Reaction with Cell-Surface Ketones: A Mathematical Model for Small-Molecule Drug Delivery. Biochim. Biophys. Acta. 2001, 1568, 147-154.

71. Sampson, N. S.; Mrksich, M.; Bertozzi, C. R. Surface Molecular Recognition. Proc. Natl. Acad. Sci. U.S.A 2001, 98, 12870-12871.

70. Marcaurelle, L. A.; Shin, Y.; Goon, S.; Bertozzi, C. R. Synthesis of Oxime-linked Mucin Mimics Containing the Tumor-related TN and Sialyl TN Antigens. Org. Lett. 2001, 3, 3691-3694.

69. Mahal, L. K.; Charter, N. W.; Angata, K.; Fukuda, M.; Koshland, D. E., Jr.; Bertozzi, C. R.  A Small Molecule Modulator of Poly-a2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells. Science 2001, 294, 380-382.

68. Jacobs, C. L.; Goon, S.; Yarema, K. J.; Hinderlich, S.; Hang, H. C.; Chai, D. H.; Bertozzi, C. R. Substrate Specificity of the Sialic Acid Biosynthetic Pathway. Biochemistry 2001, 40, 12864-12874.

67. Saxon, E.; Bertozzi, C. R. Chemical and Biological Strategies for Engineering Cell Surface Glycosylation. Ann. Rev. Cell Dev. Biol. 2001, 17, 1-23.

66. Schilling, B.; Goon, S.; Samuels, N. M.; Gaucher, S. P.; Leary, J. A.; Bertozzi, C. R.; Gibson, B. W. Biosynthesis of Sialylated Lipooligosaccharides in Haemophilus ducreyi is Dependent on Exogenous Sialic Acid and not Mannosamine. Biochemistry 2001, 40, 12666-12677.

65. Bruehl, R. E.; Dasgupta, F.; Katsumoto, T. R.; Tan, J. H.; Bertozzi, C. R.; Spevak, W.; Ahn, D. J.; Rosen, S. D.; Nagy, J. O. Polymerized Liposome Assemblies: Bifunctional Macromolecular Selectin Inhibitors Mimicking Physiological Selectin Ligands. Biochemistry 2001, 40, 5964-5974.

64. Armstrong, J. I.; Ge, X.; Verdugo, D. E.; Winans, K. A.; Leary, J. A.; Bertozzi, C. R. A Library Approach to the Generation of Bisubstrate Analog Sulfotransferase Inhibitors. Org. Lett. 2001, 3, 2657-2660.

63. Verdugo, D. E.; Cancilla, M. T.; Ge, X.; Gray, N. S.; Chang, Y.-T.; Schultz, P. G.; Negishi, M.; Leary, J. A.; Bertozzi, C. R. Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen. J. Med. Chem., 2001, 44, 2683-2686.

62. Hang, H. C.; Bertozzi, C. R. Chemoselective Approaches to Glycoprotein Engineering. Accounts Chem. Res. 2001, 34, 727-736.

61. Groves, J. T.; Mahal, L. K.; Bertozzi, C. R. Control of Cell Adhesion and Growth with Micropatterned Supported Lipid Membranes. Langmuir 2001, 17, 5129-5133.

60. Yarema, K. J.; Goon, S.; Bertozzi, C. R. Metabolic Selection of Glycosylation Defects in Human Cells. Nature Biotechnol. 2001, 19, 553-558.

59. Yarema, K. J.; Bertozzi, C. R. Characterizing Glycosylation Pathways. Genome Biology 2001, 2, 0004.1-0004.10.

58. Lemieux, G. A.; Bertozzi, C. R. Modulating Cell Surface Immunoreactivity by Metabolic Induction of Unnatural Carbohydrate Antigens. Chem. Biol. 2001, 8, 265-275.

57. Bertozzi, C. R.; Kiessling, L. L. Chemical Glycobiology. Science 2001, 291, 2357-2364.

56. Marcaurelle, L. A.; Bertozzi, C. R. Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc. J. Am. Chem. Soc. 2001, 123, 1587-1595.

55. Marcaurelle, L. A.; Mizoue, L. S.; Wilken, J.; Oldham, L.; Kent, S. B. H.; Handel, T. M.; Bertozzi, C. R.  Chemical Synthesis of Lymphotactin, a Glycosylated Chemokine with a C-terminal Mucin-like Domain.  Chem. Eur. J. 2001, 7, 1129-1132.

54. Hang, H. C., Bertozzi, C. R.  Ketone Isosteres of 2-N-Acetamidosugars as Substrates for Metabolic Cell Surface Engineering. J. Am. Chem. Soc. 2001, 123, 1242-1243.

53. Bowman, K. G.; Cook, B. N.; de Graffenried, C. L.; Bertozzi, C. R.  Biosynthesis of L-selectin Ligands: Sulfation of Sialyl Lewis x-Related Oligosaccharides by a Family of GlcNAc-6-Sulfotransferases. Biochemistry 2001, 40, 5382-5391.

52. Bruehl, R. E.; Bertozzi, C. R.; Rosen, S. D.  Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody.  J. Biol. Chem. 2000, 275, 32642-32648.

51. Bhakta, S.; Bartes, A.; Bowman, K. G.; Kao, W.-M.; Polsky, I.; Lee, J. K.; Cook, B. N.; Bruehl, R.; Rosen, S. D.; Bertozzi, C. R.; Hemmerich, S.  Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST5).  J. Biol. Chem. 2000, 275, 40226-40234.

50. Macmillan, D.; Bertozzi, C. R.  New Directions in Glycoprotein Engineering.  Tetrahedron 2000, 56, 9515-9525.

49. Cook, B. N.; Bhakta, S.; Biegel, T.; Bowman, K. G.; Armstrong, J. I.; Hemmerich, S.; Bertozzi, C. R.  Differential Carbohydrate Recognition of Two GlcNAc-6-Sulfotransferases with Possible Roles in L-Selectin Ligand Biosynthesis.  J. Am. Chem. Soc. 2000, 122, 8612-8622.

48. Armstrong, J. I.; Bertozzi, C. R.  Sulfotransferases as Targets for Therapeutic Intervention.  Curr. Opin. Drug Disc. Dev. 2000, 3, 502-515.

47. *Charter, N. W.; *Mahal, L. K.; Koshland, D. E., Jr.; Bertozzi, C. R. Biosynthetic Incorporation of Unnatural Sialic Acids into Polysialic Acid on Neural Cells. Glycobiology, 2000, 10, 1-8.

46. Jacobs, C. J.; Yarema, K. J.; Mahal, L. K.; Nauman, D. A.; Charters, N.; Bertozzi, C. R. Metabolic Labeling of Glycoproteins with Chemical Tags through Unnatural Sialic Acid Biosynthesis. Meth. Enzymol. 2000, 327, 260-275.

45. Saxon, E.; Armstrong, J. I.; Bertozzi, C. R. A "Traceless" Staudinger Ligation for the Chemoselective Synthesis of Amide Bonds. Org. Lett. 2000, 2, 2141-2143.

44. Saxon, E.; Bertozzi, C. R. Cell Surface Engineering by a Modified Staudinger Reaction. Science 2000, 287, 2007-2010.

43. Armstrong, J. I.; Portley, A. R.; Chang, Y.-T.; Nierengarten, D. M.; Cook, B. N.; Bowman, K. G.; Bishop, A.; Gray, N. S.; Shokat, K. M.; Schultz, P. G.; Bertozzi, C. R. Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library. Angew. Chem., Int. Ed. 2000, 39, 1303-1306.

42. Kehoe, J. W.; Bertozzi, C. R. Tyrosine Sulfation: A Modulator of Extracellular Protein-Protein Interactions. Chem. Biol. 2000, 7, R57-R61.

41. Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R. Fmoc-Based Synthesis of Peptide-aThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation. J. Am. Chem. Soc. 1999, 121, 11684-11689.

40. Mahal, L. K.; Yarema, K. J.; Lemieux, G. A.; Bertozzi, C. R. Chemical Approaches to Glycobiology: Engineering Cell Surface Sialic Acids for Tumor Targeting, in Sialobiology and Other Novel Forms of Glycosylation, Inoue, Y.; Lee, Y. C.; Troy, F. A., III, eds. Gakushin Publishing Company: Osaka, 1999, pp. 237-280.

39. Winans, K. A.; King, D. A.; Rao, V.; Bertozzi, C. R. A Chemically Synthesized Version of the Insect Antibacterial Glycopeptide, Diptericin, Disrupts Bacterial Membrane Integrity. Biochemistry 1999, 38, 11700-11710.

38. Lee, J. H.; Baker, T. J.; Mahal, L. K.; Zabner, J.; Bertozzi, C. R.; Wiemer, D. F.; Welsh, M. J. Engineering Novel Cell Surface Receptors for Virus-Mediated Gene Transfer. J. Biol. Chem. 1999, 274, 21878-21884.

37. Lemieux, G. A.; Yarema, K. J.; Jacobs, C. L.; Bertozzi, C. R. Exploiting Differences in Sialoside Expression for Selective Targeting of MRI Contrast Reagents. J. Am. Chem. Soc. 1999, 121, 4278-4279.

36. Marcaurelle, L. A.; Bertozzi, C. R. New Directions in the Synthesis of Glycopeptide Mimetics. Chem. Eur. J. 1999, 5, 1384-1390.

35. Chen, Q.; Zhang, D.; Somorjai, G.; Bertozzi, C. R. Probing the Surface Structural Rearrangement of Hydrogels by Sum-Frequency Generation Spectroscopy.  J. Am. Chem. Soc. 1999, 121, 446-447.

34. Bowman, K. G.; Bertozzi, C. R. Carbohydrate Sulfotransferases: Mediators of Extracellular Communication. Chem. Biol.  1999, 6, R9-R22.

33. Winans, K. A.; Bertozzi, C. R. Inner Space Exploration: The Chemical Biologist's Guide to the Cell. Chem. Biol.  1998, 5, R313-R315.

32. Yarema, K. J.; Mahal, L. K.; Bruehl, R.; Rodriguez, E. C.; Bertozzi, C. R. Metabolic Delivery of Ketone Groups to Sialic Acid Residues. Application to Cell Surface Glycoform Engineering. J. Biol. Chem. 1998, 273, 31168-31179.

31. Marcaurelle, L. A.; Rodriguez, E. C.; Bertozzi, C. R. Synthesis of an Oxime-Linked Neoglycopeptide with Glycosylation-Dependent Activity Similar to its Native Counterpart. Tetrahedron Lett. 1998, 39, 8417-8420.

30. Rodriguez, E. C.; Marcaurelle, L. A.; Bertozzi, C. R. Aminooxy, Hydrazide and Thiosemicarbazide-Functionalized Saccharides: Versatile Reagents for Glycoconjugate Synthesis. J. Org. Chem. 1998, 63, 7134-7135.

29. Marcaurelle, L. A.; Bertozzi, C. R. Direct Incorporation of Unprotected Ketone Groups into Peptides During Solid-Phase Synthesis: Application to the One-Step Synthesis of Peptides with Two Different Biophysical Probes for FRET. Tetrahedron Lett. 1998, 39, 7279-7282.

28. Bowman, K. G.; Hemmerich, S.; Bhakta, S.; Singer, M. S.; Rosen, S. D.; Bertozzi, C. R. Identification of an N-Acetylglucosamine-6-O-Sulfotransferase Activity Restricted to Lymphoid Tissue: An Enzyme with a Possible Role in Lymphocyte Homing. Chem. Biol. 1998, 5, 447-460.

27. Lemieux, G. A. ; Bertozzi, C. R. Chemoselective Ligation Reactions with Proteins, Oligosaccharides and Cells. Trends Biotech. 1998, 16, 506-513.

26. Yarema, K. J.; Bertozzi, C. R. Chemical Approaches to Glycobiology and Emerging Carbohydrate-Based Therapeutic Agents. Curr. Opin. Chem. Biol. 1998, 2, 49-61.

25. Rodriguez, E. C.; Winans, K. A.; King, D. S.; Bertozzi, C. R. A Strategy for the Chemoselective Synthesis of O-Linked Glycopeptides with Native Sugar-Peptide Linkages. J. Am. Chem. Soc. 1997, 119, 9905-9906.

24. Mahal, L. K.; Bertozzi, C. R. Engineered Cell Surfaces:  Fertile Ground for Molecular Landscaping. Chem. Biol. 1997, 4, 415-422.

23. Mahal, L. K.; Yarema, K. J.; Bertozzi, C. R. Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis. Science 1997, 276, 1125-1128.

22. Bertozzi, C. R.; Singer, M. S.; Rosen, S. D. An ELISA for Selectin Inhibitors Based on Binding to a Physiological Ligand. J. Immunol. Meth. 1997, 203, 157-165.

21. Sanders, W. J.; Katsumoto, T. R.; Bertozzi, C. R.; Rosen, S. D.; Kiessling, L. L.  L-Selectin-Carbohydrate Interactions: An Investigation into the Relevant Modifications of the Lewis x Trisaccharide. Biochemistry 1996, 35, 14862-14867.

20. Roe, B. A.; Boojamra, D. G.; Griggs, J.; Bertozzi, C. R. Synthesis of beta-C-Glycosides of N-acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups. J. Org. Chem. 1996, 61, 6442-6445.

19. Manning, D. D.; Bertozzi, C. R.; Rosen, S. D.; Kiessling, L. L. Tin Mediated Phosphorylation:  Synthesis and Selectin Binding of a Phospho Lewis a Analog. Tetrahedron Lett. 1996, 37, 1953-1956.

18. Rosen, S. D.; Bertozzi, C. R. Leukocyte Adhesion: Two Selectins Converge on Sulphate. Current Biol. 1996, 6, 261-264.

17. Kobertz, W. R.; Bertozzi, C. R.; Bednarski, M. D. C-Glycosyl Aldehydes: Synthons for C-linked Disaccharides. J. Org. Chem. 1996, 61, 1894-1897.

16. Bertozzi, C. R.; Bednarski, M. D. "Synthesis of C-Glycosides: Stable Mimics of O-Glycosidic Linkages" in Modern Methods in Carbohydrate Synthesis, Khan, S. H.; O'Neill, R. A., eds. Harwood Academic Publishers GmbH: Amsterdam, 1996, pp 316-351.

15. Bertozzi, C. R. Cracking the Carbohydrate Code for Selectin Recognition. Chem. Biol.  1995, 2, 703-708.

14. Bertozzi, C. R.; Fukuda, S.; Rosen, S. D. Sulfated Disaccharide Inhibitors of L-Selectin: Deriving Structural Leads from a Physiological Selectin Ligand. Biochemistry  1995, 34, 14271-14278.

13. Manning, D. D.; Bertozzi, C. R.; Pohl, N. L.; Rosen, S. D.; Kiessling, L. L. Selectin-Saccharide Interactions: Revealing Structure-Activity Relationships with Total Synthesis. J. Org. Chem. 1995, 60, 6254-6255.

12. Rosen, S. D.; Bertozzi, C. R. The Selectins and Their Ligands. Curr. Opin. Cell Biol. 1994, 6, 663-673.

11. Hemmerich, S.; Bertozzi, C. R.; Leffler, H.; Rosen, S. D. Identification of the Sulfated Monosaccharides of GlyCAM-1, an Endothelial-Derived Ligand for L-Selectin.  Biochemistry  1994, 33, 4820-4829.

10. Grabowski, J. J.; Bertozzi, C. R.; Jacobsen, J. R.; Jain, A.; Marzluff, E. M.; Suh, A. Y. Fluorescence Probes in Biochemistry: An Examination of the Non-Fluorescent Behavior of Dansylamide by Photoacoustic Calorimetry. Analytical Biochem. 1992, 207, 214-226.

9. Bertozzi, C. R.; Cook, D. G.; Kobertz, W. R.; Gonzalez-Scarano, F.; Bednarski, M. D. Carbon-Linked Galactosphingolipid Analogs Bind Specifically to HIV-1 gp120. J. Am. Chem. Soc. 1992, 114, 10639-10641.

8. Bertozzi, C. R.; Hoeprich, P. D., Jr.; Bednarski, M. D. Synthesis of Carbon-Linked Glycopeptides as Stable Glycopeptide Models. J. Org. Chem. 1992, 57, 6092-6094.

7. Bertozzi, C. R.; Bednarski, M. D. The Synthesis of 2-Azido C-Glycosyl Sugars. Tetrahedron Lett. 1992, 33, 3109-3112.

6. Bertozzi, C. R.; Bednarski, M. D. A Receptor-Mediated Immune Response Using Synthetic Glycoconjugates. J. Am. Chem. Soc. 1992, 114, 5543-5546.

5. Bertozzi, C. R.; Bednarski, M. D. Antibody Targeting to Bacterial Cells Using Receptor-Specific Ligands. J. Am. Chem. Soc. 1992, 114, 2242-2245.

4. Kobertz, W. R.; Bertozzi, C. R.; Bednarski, M. D. An Efficient Method for the Synthesis of alpha- and beta-C-Glycosyl Aldehydes. Tetrahedron Lett. 1992, 33, 737-740.

3. Bertozzi, C. R.; Bednarski, M. D. C-Glycosyl Compounds Bind to Receptors on the Surface of Escherichia coli and can Target Proteins to the Organism. Carbohydrate Res. 1992, 223, 243-253.

2. Bertozzi, C. R.; Bednarski, M. D. The Synthesis of Heterobifunctional Linkers for the Conjugation of Ligands to Molecular Probes. J. Org. Chem.  1991, 56, 4326-4329.

1. Chidsey, C. E. D.; Bertozzi, C. R.; Putvinski, T. M.; Mujsce, A. M. Coadsorption of Ferrocene-Terminated and Unsubstituted Alkanethiols on Gold: Electroactive Self-Assembled Monolayers. J. Am. Chem. Soc.  1990, 112, 4301-4306.