Research Interests

In the 21st century, explorations at the interface of chemistry and biology will spawn new medicines and diagnostics that improve human health, technologies for probing natural biology, and roadmaps for creating synthetic forms of life engineered to serve human needs. The Bertozzi lab focuses on creating new platform technologies that promote these endeavors, as well as applying chemical approaches to study systems that elude more conventional methods of biological inquiry. Examples of technologies that drive our research are bioorthogonal chemistries, site-specific protein modification methods, and synthetic glycopolymers that emulate cell-surface glycoproteins. More information on these tools and their applications in our lab, particularly in the area of glycoscience, can be found by clicking the images below.

Decoding the cancer glycocalyx

Targeted degradation strategies

Uncovering the mucinome

Chemical glycoproteomics

Mycobacterial glycoscience

Other therapeutic opportunities in glycoscience